Cell atlas - PAPOLG - The Human Protein Atlas

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PAPOLG

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PAPOLG
Gene description	Poly(A) polymerase gamma
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA035349 , HPA035350
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA035349	A-431	Nucleoplasm
		Nuclear bodies
		Cytosol
HPA035349	HEK 293	No staining
HPA035349	U-2 OS	Nucleus	Intensity
HPA035350	A-431	Nucleoplasm
HPA035350	A-431	Cytosol
HPA035350	HEK 293	Nucleoplasm
HPA035350	U-2 OS	Nucleoplasm

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000020273 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA035350	NIH 3T3	Nucleoplasm
	HPA035350	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	PAPOLG (HGNC Symbol)
Synonyms	FLJ12972
Description	Poly(A) polymerase gamma (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p16.1
Chromosome location (bp)	60756230 - 60802085
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115421 (version 83.38)
Entrez gene	64895
UniProt	Q9BWT3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BWT3
Antibodypedia	PAPOLG antibodies

PROTEIN BROWSER

PAPOLG-001	PAPOLG-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAPOLG-001 ENSP00000238714 ENST00000238714	Q9BWT3 [Direct mapping] Poly(A) polymerase gamma Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004652 [polynucleotide adenylyltransferase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006378 [mRNA polyadenylation] GO:0016020 [membrane] GO:0016779 [nucleotidyltransferase activity] GO:0031123 [RNA 3'-end processing] GO:0043631 [RNA polyadenylation] GO:0046872 [metal ion binding] Show all	736 aa 82.8 kDa	No	1
PAPOLG-005 ENSP00000405570 ENST00000412217	A0A0C4DH56 [Direct mapping] Poly(A) polymerase gamma Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004652 [polynucleotide adenylyltransferase activity] GO:0005634 [nucleus] GO:0006378 [mRNA polyadenylation] GO:0016779 [nucleotidyltransferase activity] GO:0031123 [RNA 3'-end processing] GO:0043631 [RNA polyadenylation] Show all	382 aa 42.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.