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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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IGFBP5
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

IGFBP5

Gene description

Insulin-like growth factor binding protein 5

Protein class

Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (cervix, uterine, ovary)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Mainly expression of neuronal processes in CNS and extracellular expression in several tissues.

DATA RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. External data supports expression in CNS.

Reliability score

Approved based on 1 antibody.
CAB009216
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine, ovary)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

IGFBP5

Synonyms

Description

Insulin-like growth factor binding protein 5 (HGNC Symbol)

Entrez gene summary

Chromosome

2

Cytoband

q35

Chromosome location (bp)

216672105 - 216695525

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115461 (version 83.38)

Entrez gene

3488

UniProt

P24593 (UniProt - Evidence at protein level)

neXtProt

NX_P24593

Antibodypedia

IGFBP5 antibodies

PROTEIN BROWSER

IGFBP5-001
IGFBP5-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IGFBP5-001
ENSP00000233813
ENST00000233813
P24593 [Direct mapping]
Insulin-like growth factor-binding protein 5
A0A024R433 [Target identity:100%; Query identity:100%]
Insulin-like growth factor binding protein 5, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001649 [osteoblast differentiation]
GO:0001968 [fibronectin binding]
GO:0005515 [protein binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006006 [glucose metabolic process]
GO:0007165 [signal transduction]
GO:0007565 [female pregnancy]
GO:0010906 [regulation of glucose metabolic process]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0016942 [insulin-like growth factor binding protein complex]
GO:0017148 [negative regulation of translation]
GO:0030336 [negative regulation of cell migration]
GO:0031069 [hair follicle morphogenesis]
GO:0031994 [insulin-like growth factor I binding]
GO:0031995 [insulin-like growth factor II binding]
GO:0035556 [intracellular signal transduction]
GO:0040008 [regulation of growth]
GO:0042567 [insulin-like growth factor ternary complex]
GO:0042593 [glucose homeostasis]
GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway]
GO:0043569 [negative regulation of insulin-like growth factor receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0044342 [type B pancreatic cell proliferation]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045926 [negative regulation of growth]
GO:0048286 [lung alveolus development]
GO:0048630 [skeletal muscle tissue growth]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0051146 [striated muscle cell differentiation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060056 [mammary gland involution]
GO:0060416 [response to growth hormone]
GO:0071320 [cellular response to cAMP]
GO:0071407 [cellular response to organic cyclic compound]
GO:1901862 [negative regulation of muscle tissue development]
GO:1904205 [negative regulation of skeletal muscle hypertrophy]
Show all
272 aa
30.6 kDa
Yes 0
IGFBP5-003
ENSP00000413474
ENST00000449583
C9JXX4 [Direct mapping]
Insulin-like growth factor-binding protein 5
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001968 [fibronectin binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0031995 [insulin-like growth factor II binding]
Show all
233 aa
25.5 kDa
Yes 0

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The Human Protein Atlas project is funded
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