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TXNDC9

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GENERAL INFORMATION

Gene name

 TXNDC9

Gene description

 Thioredoxin domain containing 9

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (validated)

siRNA

 The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA031846
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ASSAYS
RNA expression
Human cells
siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA031846 A-431 Cytosol
HPA031846 U-2 OS Cytosol
HPA031846 U-251 MG Cytosol

siRNA VALIDATION
 

Relative fluorescence intensity (RFI)

Antibody

 HPA031846

siRNA validation

 Validated: Significant downregulation > 25% by one siRNA.

Analysis performed in

 Cytoplasmic region of segmented cells in 10x-images

siRNA 2

RFI

 72%

p-value

 < 0.01
 

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Sample

Cell line
HPA031846 siRNA 2 U-2 OS
HPA031846 scrambled U-2 OS

GENE INFORMATION

Gene name

 TXNDC9 (HGNC Symbol)

Synonyms

 APACD

Description

 Thioredoxin domain containing 9 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the thioredoxin family. The exact function of this protein is not known but it is associated with cell differentiation. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q11.2

Chromosome location (bp)

 99318982 - 99340702

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115514 (version 83.38)

Entrez gene

 10190

UniProt

 O14530 (UniProt - Evidence at protein level)

neXtProt

 NX_O14530

Antibodypedia

 TXNDC9 antibodies

PROTEIN BROWSER
TXNDC9-001
TXNDC9-002
TXNDC9-004
TXNDC9-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TXNDC9-001
ENSP00000264255
ENST00000264255
O14530 [Direct mapping]
Thioredoxin domain-containing protein 9
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0008150 [biological_process]
GO:0030496 [midbody]
GO:0045454 [cell redox homeostasis]
Show all
 226 aa
26.5 kDa 		No 0
TXNDC9-002
ENSP00000387275
ENST00000409434
O14530 [Direct mapping]
Thioredoxin domain-containing protein 9
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0008150 [biological_process]
GO:0030496 [midbody]
GO:0045454 [cell redox homeostasis]
Show all
 188 aa
22.2 kDa 		No 0
TXNDC9-004
ENSP00000386889
ENST00000409705
B8ZZX4 [Direct mapping]
Thioredoxin domain-containing protein 9
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 135 aa
16.1 kDa 		No 0
TXNDC9-006
ENSP00000406388
ENST00000434323
F8WCJ3 [Direct mapping]
Thioredoxin domain-containing protein 9
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 122 aa
14.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.