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SF3B1

GENERAL INFORMATION

Gene name

 SF3B1

Gene description

 Splicing factor 3b, subunit 1, 155kDa

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA050275
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SF3B1 (HGNC Symbol)

Synonyms

 Hsh155, Prp10, PRPF10, SAP155, SF3b155

Description

 Splicing factor 3b, subunit 1, 155kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q33.1

Chromosome location (bp)

 197389784 - 197435091

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115524 (version 83.38)

Entrez gene

 23451

UniProt

 O75533 (UniProt - Evidence at protein level)

neXtProt

 NX_O75533

Antibodypedia

 SF3B1 antibodies

PROTEIN BROWSER
SF3B1-001
SF3B1-004
SF3B1-005
SF3B1-012
SF3B1-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SF3B1-001
ENSP00000335321
ENST00000335508
O75533 [Direct mapping]
Splicing factor 3B subunit 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000245 [spliceosomal complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000785 [chromatin]
GO:0001825 [blastocyst formation]
GO:0003682 [chromatin binding]
GO:0003729 [mRNA binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005686 [U2 snRNP]
GO:0005689 [U12-type spliceosomal complex]
GO:0008380 [RNA splicing]
GO:0009952 [anterior/posterior pattern specification]
GO:0010467 [gene expression]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0030532 [small nuclear ribonucleoprotein complex]
GO:0034693 [U11/U12 snRNP]
GO:0044822 [poly(A) RNA binding]
GO:0071004 [U2-type prespliceosome]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 1304 aa
145.8 kDa 		No 2
SF3B1-004
ENSP00000419896
ENST00000487698
B4DGZ4 [Direct mapping]
Splicing factor 3B subunit 1; cDNA FLJ57368, highly similar to Splicing factor 3B subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
Show all
 154 aa
17.4 kDa 		No 0
SF3B1-005
ENSP00000428820
ENST00000409915
O75533 [Direct mapping]
Splicing factor 3B subunit 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000245 [spliceosomal complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005686 [U2 snRNP]
GO:0005689 [U12-type spliceosomal complex]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0034693 [U11/U12 snRNP]
GO:0044822 [poly(A) RNA binding]
GO:0071004 [U2-type prespliceosome]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 144 aa
16 kDa 		No 0
SF3B1-012
ENSP00000409435
ENST00000424674
H7C341 [Direct mapping]
Splicing factor 3B subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
Show all
 241 aa
27.2 kDa 		No 0
SF3B1-014
ENSP00000402997
ENST00000414963
O75533 [Direct mapping]
Splicing factor 3B subunit 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000245 [spliceosomal complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005686 [U2 snRNP]
GO:0005689 [U12-type spliceosomal complex]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0034693 [U11/U12 snRNP]
GO:0044822 [poly(A) RNA binding]
GO:0071004 [U2-type prespliceosome]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 144 aa
16 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.