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PLCD4

GENERAL INFORMATION

Gene name

 PLCD4

Gene description

 Phospholipase C, delta 4

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skeletal muscle)
GTEx:Tissue enhanced (skeletal muscle)
FANTOM5:Tissue enhanced (retina, smooth muscle, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in selected tissues, most abundant in skeletal muscle. fibroblasts

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 3 antibodies.
HPA038139 , HPA038140 , CAB009914
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (retina, smooth muscle, skeletal muscle)

GENE INFORMATION

Gene name

 PLCD4

Synonyms

Description

 Phospholipase C, delta 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 218607765 - 218637184

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115556 (version 83.38)

Entrez gene

 84812

UniProt

 Q9BRC7 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9BRC7

Antibodypedia

 PLCD4 antibodies

PROTEIN BROWSER
PLCD4-001
PLCD4-006
PLCD4-007
PLCD4-011
PLCD4-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLCD4-001
ENSP00000388631
ENST00000450993
Q9BRC7 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0007340 [acrosome reaction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0031965 [nuclear membrane]
GO:0035556 [intracellular signal transduction]
GO:0046488 [phosphatidylinositol metabolic process]
Show all
 762 aa
87.6 kDa 		No 0
PLCD4-006
ENSP00000396942
ENST00000417849
Q9BRC7 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0031965 [nuclear membrane]
GO:0035556 [intracellular signal transduction]
GO:0046488 [phosphatidylinositol metabolic process]
Show all
 762 aa
87.6 kDa 		No 0
PLCD4-007
ENSP00000396185
ENST00000432688
C9JEA7 [Direct mapping]
Phosphoinositide phospholipase C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0031965 [nuclear membrane]
GO:0035556 [intracellular signal transduction]
Show all
 794 aa
91 kDa 		No 0
PLCD4-011
ENSP00000391850
ENST00000415854
C9JAE4 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004629 [phospholipase C activity]
GO:0005622 [intracellular]
GO:0007340 [acrosome reaction]
GO:0035556 [intracellular signal transduction]
GO:0046488 [phosphatidylinositol metabolic process]
Show all
 99 aa
11.5 kDa 		No 0
PLCD4-015
ENSP00000404481
ENST00000457773
H7C281 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004629 [phospholipase C activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007340 [acrosome reaction]
GO:0035556 [intracellular signal transduction]
GO:0046488 [phosphatidylinositol metabolic process]
Show all
 111 aa
12.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.