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CHMP3

GENERAL INFORMATION

Gene name

 CHMP3

Gene description

 Charged multivesicular body protein 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 1 antibody.
HPA015673
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CHMP3 (HGNC Symbol)

Synonyms

 CGI-149, NEDF, VPS24

Description

 Charged multivesicular body protein 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010]

Chromosome

 2

Cytoband

 p11.2

Chromosome location (bp)

 86503431 - 86563479

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115561 (version 83.38)

Entrez gene

 51652

UniProt

 Q9Y3E7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y3E7

Antibodypedia

 CHMP3 antibodies

PROTEIN BROWSER
CHMP3-001
CHMP3-002
CHMP3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHMP3-001
ENSP00000263856
ENST00000263856
Q9Y3E7 [Direct mapping]
Charged multivesicular body protein 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000815 [ESCRT III complex]
GO:0000920 [cell separation after cytokinesis]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0007034 [vacuolar transport]
GO:0010824 [regulation of centrosome duplication]
GO:0015031 [protein transport]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0019058 [viral life cycle]
GO:0031210 [phosphatidylcholine binding]
GO:0031902 [late endosome membrane]
GO:0039702 [viral budding via host ESCRT complex]
GO:0042803 [protein homodimerization activity]
GO:0050792 [regulation of viral process]
GO:0051258 [protein polymerization]
GO:0051291 [protein heterooligomerization]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:1902187 [negative regulation of viral release from host cell]
GO:1902188 [positive regulation of viral release from host cell]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 222 aa
25.1 kDa 		No 0
CHMP3-002
ENSP00000386590
ENST00000409225
Q9Y3E7 [Direct mapping]
Charged multivesicular body protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000815 [ESCRT III complex]
GO:0000920 [cell separation after cytokinesis]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0007034 [vacuolar transport]
GO:0010824 [regulation of centrosome duplication]
GO:0015031 [protein transport]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0019058 [viral life cycle]
GO:0031210 [phosphatidylcholine binding]
GO:0031902 [late endosome membrane]
GO:0039702 [viral budding via host ESCRT complex]
GO:0042803 [protein homodimerization activity]
GO:0050792 [regulation of viral process]
GO:0051258 [protein polymerization]
GO:0051291 [protein heterooligomerization]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:1902187 [negative regulation of viral release from host cell]
GO:1902188 [positive regulation of viral release from host cell]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 156 aa
17.3 kDa 		No 0
CHMP3-003
ENSP00000387045
ENST00000409727
Q9Y3E7 [Direct mapping]
Charged multivesicular body protein 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000815 [ESCRT III complex]
GO:0000920 [cell separation after cytokinesis]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0007034 [vacuolar transport]
GO:0010824 [regulation of centrosome duplication]
GO:0015031 [protein transport]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0019058 [viral life cycle]
GO:0031210 [phosphatidylcholine binding]
GO:0031902 [late endosome membrane]
GO:0039702 [viral budding via host ESCRT complex]
GO:0042803 [protein homodimerization activity]
GO:0050792 [regulation of viral process]
GO:0051258 [protein polymerization]
GO:0051291 [protein heterooligomerization]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:1902187 [negative regulation of viral release from host cell]
GO:1902188 [positive regulation of viral release from host cell]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 182 aa
20.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.