Expression of IL1RL1 in cancer - Summary

CANCER ATLAS

Gene description

Interleukin 1 receptor-like 1

Protein class

Candidate cardiovascular disease genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Urothelial cancer

STAINING SUMMARY

HPA007406	HPA007917

GENE INFORMATION
Gene name	IL1RL1 (HGNC Symbol)
Synonyms	DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1
Description	Interleukin 1 receptor-like 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q12.1
Chromosome location (bp)	102311502 - 102352037
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115602 (version 83.38)
Entrez gene	9173
UniProt	Q01638 (UniProt - Evidence at protein level)
neXtProt	NX_Q01638
Antibodypedia	IL1RL1 antibodies

PROTEIN BROWSER

IL1RL1-001	IL1RL1-002	IL1RL1-004	IL1RL1-008	IL1RL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL1RL1-001 ENSP00000233954 ENST00000233954	Q01638 [Direct mapping] Interleukin-1 receptor-like 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002113 [interleukin-33 binding] GO:0002114 [interleukin-33 receptor activity] GO:0002826 [negative regulation of T-helper 1 type immune response] GO:0004896 [cytokine receptor activity] GO:0004908 [interleukin-1 receptor activity] GO:0005057 [receptor signaling protein activity] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0008285 [negative regulation of cell proliferation] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032689 [negative regulation of interferon-gamma production] GO:0032754 [positive regulation of interleukin-5 production] GO:0035556 [intracellular signal transduction] GO:0038172 [interleukin-33-mediated signaling pathway] GO:0043032 [positive regulation of macrophage activation] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0050729 [positive regulation of inflammatory response] GO:0090197 [positive regulation of chemokine secretion] GO:1901653 [cellular response to peptide] Show all	556 aa 63.4 kDa	Yes	1
IL1RL1-002 ENSP00000310371 ENST00000311734	Q01638 [Direct mapping] Interleukin-1 receptor-like 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004896 [cytokine receptor activity] GO:0004908 [interleukin-1 receptor activity] GO:0005057 [receptor signaling protein activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0035556 [intracellular signal transduction] Show all	328 aa 37 kDa	Yes	0
IL1RL1-004 ENSP00000409437 ENST00000447231	C9JSY6 [Direct mapping] Interleukin-1 receptor-like 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		38 aa 4.4 kDa	Yes	0
IL1RL1-008 ENSP00000386618 ENST00000409584	E9PC41 [Direct mapping] Interleukin-1 receptor-like 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004908 [interleukin-1 receptor activity] GO:0005515 [protein binding] GO:0019221 [cytokine-mediated signaling pathway] Show all	314 aa 35.6 kDa	Yes	0
IL1RL1-201 ENSP00000384822 ENST00000404917	Q01638 [Direct mapping] Interleukin-1 receptor-like 1 Show all	Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004896 [cytokine receptor activity] GO:0004908 [interleukin-1 receptor activity] GO:0005057 [receptor signaling protein activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0035556 [intracellular signal transduction] Show all	211 aa 23.7 kDa	No	0