Expression of IL18RAP in cancer - Summary

CANCER ATLAS

Gene description

Interleukin 18 receptor accessory protein

Protein class

CD markers, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB025270

GENE INFORMATION
Gene name	IL18RAP (HGNC Symbol)
Synonyms	AcPL, CD218b
Description	Interleukin 18 receptor accessory protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
Chromosome	2
Cytoband	q12.1
Chromosome location (bp)	102418689 - 102452565
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115607 (version 83.38)
Entrez gene	8807
UniProt	O95256 (UniProt - Evidence at protein level)
neXtProt	NX_O95256
Antibodypedia	IL18RAP antibodies

PROTEIN BROWSER

IL18RAP-001	IL18RAP-002	IL18RAP-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL18RAP-001 ENSP00000264260 ENST00000264260	O95256 [Direct mapping] Interleukin-18 receptor accessory protein Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0070301 [cellular response to hydrogen peroxide] GO:0071345 [cellular response to cytokine stimulus] Show all	599 aa 68.3 kDa	Yes	1
IL18RAP-002 ENSP00000387201 ENST00000409369	O95256 [Direct mapping] Interleukin-18 receptor accessory protein Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	457 aa 51.9 kDa	No	1
IL18RAP-003 ENSP00000389815 ENST00000450855	C9JLE2 [Direct mapping] Interleukin-18 receptor accessory protein Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all		44 aa 5.1 kDa	Yes	0