Tissue expression of UXS1 - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

UXS1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	UXS1
Gene description	UDP-glucuronate decarboxylase 1
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA008825
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	UXS1 (HGNC Symbol)
Synonyms	FLJ23591, SDR6E1, UGD
Description	UDP-glucuronate decarboxylase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme found in the perinuclear Golgi which catalyzes the synthesis of UDP-xylose used in glycosaminoglycan (GAG) synthesis on proteoglycans. The GAG chains are covalently attached to proteoglycans which participate in signaling pathways during development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Chromosome	2
Cytoband	q12.2
Chromosome location (bp)	106093303 - 106194339
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115652 (version 83.38)
Entrez gene	80146
UniProt	Q8NBZ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NBZ7
Antibodypedia	UXS1 antibodies

PROTEIN BROWSER

UXS1-001	UXS1-003	UXS1-004	UXS1-006	UXS1-008	UXS1-009	UXS1-012	UXS1-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UXS1-001 ENSP00000283148 ENST00000283148	Q8NBZ7 [Direct mapping] UDP-glucuronic acid decarboxylase 1 Show all	Enzymes ENZYME proteins Lyases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005739 [mitochondrion] GO:0005794 [Golgi apparatus] GO:0016021 [integral component of membrane] GO:0032580 [Golgi cisterna membrane] GO:0033320 [UDP-D-xylose biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0048040 [UDP-glucuronate decarboxylase activity] GO:0050662 [coenzyme binding] GO:0051262 [protein tetramerization] GO:0070062 [extracellular exosome] GO:0070403 [NAD+ binding] Show all	425 aa 48.2 kDa	Yes	0
UXS1-003 ENSP00000387019 ENST00000409501	Q8NBZ7 [Direct mapping] UDP-glucuronic acid decarboxylase 1 Show all	Enzymes ENZYME proteins Lyases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0016021 [integral component of membrane] GO:0032580 [Golgi cisterna membrane] GO:0033320 [UDP-D-xylose biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0048040 [UDP-glucuronate decarboxylase activity] GO:0050662 [coenzyme binding] GO:0051262 [protein tetramerization] GO:0070062 [extracellular exosome] GO:0070403 [NAD+ binding] Show all	420 aa 47.6 kDa	Yes	0
UXS1-004 ENSP00000387096 ENST00000409032	Q8NBZ7 [Direct mapping] UDP-glucuronic acid decarboxylase 1 Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0016021 [integral component of membrane] GO:0032580 [Golgi cisterna membrane] GO:0033320 [UDP-D-xylose biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0048040 [UDP-glucuronate decarboxylase activity] GO:0050662 [coenzyme binding] GO:0051262 [protein tetramerization] GO:0070062 [extracellular exosome] GO:0070403 [NAD+ binding] Show all	252 aa 28.3 kDa	No	0
UXS1-006 ENSP00000399316 ENST00000457835	C9JW33 [Direct mapping] UDP-glucuronic acid decarboxylase 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0048040 [UDP-glucuronate decarboxylase activity] GO:0050662 [coenzyme binding] Show all	190 aa 21.7 kDa	No	0
UXS1-008 ENSP00000403612 ENST00000416298	C9JCB7 [Direct mapping] UDP-glucuronic acid decarboxylase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0050662 [coenzyme binding] Show all	134 aa 15 kDa	No	0
UXS1-009 ENSP00000404468 ENST00000444193	C9JFU6 [Direct mapping] UDP-glucuronic acid decarboxylase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0050662 [coenzyme binding] Show all	121 aa 13.5 kDa	No	0
UXS1-012 ENSP00000416656 ENST00000441952	C9JE50 [Direct mapping] UDP-glucuronic acid decarboxylase 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0048040 [UDP-glucuronate decarboxylase activity] GO:0050662 [coenzyme binding] Show all	171 aa 18.9 kDa	Yes	0
UXS1-013 ENSP00000397049 ENST00000436241	C9J3T9 [Direct mapping] UDP-glucuronic acid decarboxylase 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0050662 [coenzyme binding] Show all	52 aa 5.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.