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PASK

CANCER ATLAS

Gene description

 PAS domain containing serine/threonine kinase

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA016450
HPA021079

GENE INFORMATION

Gene name

 PASK (HGNC Symbol)

Synonyms

 KIAA0135, PASKIN, STK37

Description

 PAS domain containing serine/threonine kinase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 241106099 - 241150264

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115687 (version 83.38)

Entrez gene

 23178

UniProt

 Q96RG2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96RG2

Antibodypedia

 PASK antibodies

PROTEIN BROWSER
PASK-001
PASK-002
PASK-003
PASK-004
PASK-008
PASK-010
PASK-012
PASK-201
PASK-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PASK-001
ENSP00000234040
ENST00000234040
Q96RG2 [Direct mapping]
PAS domain-containing serine/threonine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006468 [protein phosphorylation]
GO:0035091 [phosphatidylinositol binding]
GO:0043576 [regulation of respiratory gaseous exchange]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0045727 [positive regulation of translation]
GO:0046777 [protein autophosphorylation]
GO:0070092 [regulation of glucagon secretion]
GO:2000505 [regulation of energy homeostasis]
Show all
 1323 aa
142.9 kDa 		No 0
PASK-002
ENSP00000384438
ENST00000403638
Q96RG2 [Direct mapping]
PAS domain-containing serine/threonine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006468 [protein phosphorylation]
GO:0035091 [phosphatidylinositol binding]
GO:0043576 [regulation of respiratory gaseous exchange]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0045727 [positive regulation of translation]
GO:0046777 [protein autophosphorylation]
GO:0070092 [regulation of glucagon secretion]
GO:2000505 [regulation of energy homeostasis]
Show all
 1143 aa
123 kDa 		No 0
PASK-003
ENSP00000384016
ENST00000405260
Q96RG2 [Direct mapping]
PAS domain-containing serine/threonine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006468 [protein phosphorylation]
GO:0035091 [phosphatidylinositol binding]
GO:0043576 [regulation of respiratory gaseous exchange]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0045727 [positive regulation of translation]
GO:0046777 [protein autophosphorylation]
GO:0070092 [regulation of glucagon secretion]
GO:2000505 [regulation of energy homeostasis]
Show all
 1323 aa
142.9 kDa 		No 0
PASK-004
ENSP00000351475
ENST00000358649
Q96RG2 [Direct mapping]
PAS domain-containing serine/threonine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006468 [protein phosphorylation]
GO:0035091 [phosphatidylinositol binding]
GO:0043576 [regulation of respiratory gaseous exchange]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0045727 [positive regulation of translation]
GO:0046777 [protein autophosphorylation]
GO:0070092 [regulation of glucagon secretion]
GO:2000505 [regulation of energy homeostasis]
Show all
 1330 aa
143.7 kDa 		No 0
PASK-008
ENSP00000400734
ENST00000415234
C9J1Z3 [Direct mapping]
PAS domain-containing serine/threonine-protein kinase
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 140 aa
15.2 kDa 		No 0
PASK-010
ENSP00000397922
ENST00000452907
C9J4R3 [Direct mapping]
PAS domain-containing serine/threonine-protein kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 125 aa
13.3 kDa 		No 0
PASK-012
ENSP00000395672
ENST00000433589
H7C0L7 [Direct mapping]
PAS domain-containing serine/threonine-protein kinase
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 193 aa
20.9 kDa 		No 0
PASK-201
ENSP00000441374
ENST00000544142
Q96RG2 [Direct mapping]
PAS domain-containing serine/threonine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006468 [protein phosphorylation]
GO:0035091 [phosphatidylinositol binding]
GO:0043576 [regulation of respiratory gaseous exchange]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0045727 [positive regulation of translation]
GO:0046777 [protein autophosphorylation]
GO:0070092 [regulation of glucagon secretion]
GO:2000505 [regulation of energy homeostasis]
Show all
 1323 aa
142.9 kDa 		No 0
PASK-202
ENSP00000486149
ENST00000629419
F8WEB4 [Direct mapping]
PAS domain-containing serine/threonine-protein kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 71 aa
7.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.