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STK25

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GENERAL INFORMATION

Gene name

 STK25

Gene description

 Serine/threonine kinase 25

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 19
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 STK25 (HGNC Symbol)

Synonyms

 SOK1, YSK1

Description

 Serine/threonine kinase 25 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 241492674 - 241509730

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115694 (version 83.38)

Entrez gene

 10494

UniProt

 O00506 (UniProt - Evidence at protein level)

neXtProt

 NX_O00506

Antibodypedia

 STK25 antibodies

PROTEIN BROWSER
«
STK25-001
STK25-002
STK25-003
STK25-004
STK25-005
STK25-007
STK25-009
STK25-010
STK25-014
STK25-016
STK25-017
STK25-018
STK25-019
STK25-020
STK25-023
STK25-026
STK25-033
STK25-201
STK25-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STK25-001
ENSP00000325748
ENST00000316586
O00506 [Direct mapping]
Serine/threonine-protein kinase 25
A0A024R4B2 [Target identity:100%; Query identity:100%]
Serine/threonine kinase 25 (STE20 homolog, yeast), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006468 [protein phosphorylation]
GO:0006979 [response to oxidative stress]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0036481 [intrinsic apoptotic signaling pathway in response to hydrogen peroxide]
GO:0042542 [response to hydrogen peroxide]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0050772 [positive regulation of axonogenesis]
GO:0051645 [Golgi localization]
GO:0051683 [establishment of Golgi localization]
GO:0070062 [extracellular exosome]
GO:0090168 [Golgi reassembly]
Show all
 426 aa
48.1 kDa 		No 0
STK25-002
ENSP00000384162
ENST00000403346
O00506 [Direct mapping]
Serine/threonine-protein kinase 25
A0A024R4B2 [Target identity:100%; Query identity:100%]
Serine/threonine kinase 25 (STE20 homolog, yeast), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006468 [protein phosphorylation]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0036481 [intrinsic apoptotic signaling pathway in response to hydrogen peroxide]
GO:0042542 [response to hydrogen peroxide]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0051645 [Golgi localization]
GO:0051683 [establishment of Golgi localization]
GO:0070062 [extracellular exosome]
GO:0090168 [Golgi reassembly]
Show all
 426 aa
48.1 kDa 		No 0
STK25-003
ENSP00000385541
ENST00000405585
O00506 [Direct mapping]
Serine/threonine-protein kinase 25
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006468 [protein phosphorylation]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0036481 [intrinsic apoptotic signaling pathway in response to hydrogen peroxide]
GO:0042542 [response to hydrogen peroxide]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0051645 [Golgi localization]
GO:0051683 [establishment of Golgi localization]
GO:0070062 [extracellular exosome]
GO:0090168 [Golgi reassembly]
Show all
 349 aa
39.3 kDa 		No 0
STK25-004
ENSP00000384444
ENST00000405883
O00506 [Direct mapping]
Serine/threonine-protein kinase 25
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006468 [protein phosphorylation]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0036481 [intrinsic apoptotic signaling pathway in response to hydrogen peroxide]
GO:0042542 [response to hydrogen peroxide]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0051645 [Golgi localization]
GO:0051683 [establishment of Golgi localization]
GO:0070062 [extracellular exosome]
GO:0090168 [Golgi reassembly]
Show all
 349 aa
39.3 kDa 		No 0
STK25-005
ENSP00000385687
ENST00000401869
O00506 [Direct mapping]
Serine/threonine-protein kinase 25
A0A024R4B2 [Target identity:100%; Query identity:100%]
Serine/threonine kinase 25 (STE20 homolog, yeast), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006468 [protein phosphorylation]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0036481 [intrinsic apoptotic signaling pathway in response to hydrogen peroxide]
GO:0042542 [response to hydrogen peroxide]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0051645 [Golgi localization]
GO:0051683 [establishment of Golgi localization]
GO:0070062 [extracellular exosome]
GO:0090168 [Golgi reassembly]
Show all
 426 aa
48.1 kDa 		No 0
STK25-007
ENSP00000403607
ENST00000442307
C9JCC0 [Direct mapping]
Serine/threonine-protein kinase 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
Show all
 163 aa
18.2 kDa 		No 0
STK25-009
ENSP00000404960
ENST00000429279
C9JJV0 [Direct mapping]
Serine/threonine-protein kinase 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
Show all
 79 aa
8.7 kDa 		No 0
STK25-010
ENSP00000404552
ENST00000420551
C9JFA1 [Direct mapping]
Serine/threonine-protein kinase 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
Show all
 89 aa
10 kDa 		No 0
STK25-014
ENSP00000414191
ENST00000426941
C9JN58 [Direct mapping]
Serine/threonine-protein kinase 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
Show all
 115 aa
13 kDa 		No 0
STK25-016
ENSP00000417020
ENST00000424537
C9J6L2 [Direct mapping]
Serine/threonine-protein kinase 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
Show all
 161 aa
18.1 kDa 		No 0
STK25-017
ENSP00000406208
ENST00000439101
C9J8E8 [Direct mapping]
Serine/threonine-protein kinase 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005622 [intracellular]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
Show all
 19 aa
2 kDa 		No 0
STK25-018
ENSP00000403866
ENST00000440109
C9JIH8 [Direct mapping]
Serine/threonine-protein kinase 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
Show all
 58 aa
6.2 kDa 		No 0
STK25-019
ENSP00000401114
ENST00000435225
C9K0M6 [Direct mapping]
Serine/threonine-protein kinase 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
Show all
 49 aa
5.5 kDa 		No 0
STK25-020
ENSP00000395104
ENST00000413760
C9JDH9 [Direct mapping]
Serine/threonine-protein kinase 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
Show all
 148 aa
16.4 kDa 		No 0
STK25-023
ENSP00000399212
ENST00000450497
C9J232 [Direct mapping]
Serine/threonine-protein kinase 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
Show all
 177 aa
19.9 kDa 		No 0
STK25-026
ENSP00000404469
ENST00000423004
H7C279 [Direct mapping]
Serine/threonine-protein kinase 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
Show all
 247 aa
27.8 kDa 		No 0
STK25-033
ENSP00000412617
ENST00000436402
E7EM58 [Direct mapping]
Serine/threonine-protein kinase 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
Show all
 152 aa
17.3 kDa 		No 0
STK25-201
ENSP00000446008
ENST00000535007
O00506 [Direct mapping]
Serine/threonine-protein kinase 25
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006468 [protein phosphorylation]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0036481 [intrinsic apoptotic signaling pathway in response to hydrogen peroxide]
GO:0042542 [response to hydrogen peroxide]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0051645 [Golgi localization]
GO:0051683 [establishment of Golgi localization]
GO:0070062 [extracellular exosome]
GO:0090168 [Golgi reassembly]
Show all
 332 aa
37.3 kDa 		No 0
STK25-202
ENSP00000444886
ENST00000543554
O00506 [Direct mapping]
Serine/threonine-protein kinase 25
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006468 [protein phosphorylation]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0036481 [intrinsic apoptotic signaling pathway in response to hydrogen peroxide]
GO:0042542 [response to hydrogen peroxide]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0051645 [Golgi localization]
GO:0051683 [establishment of Golgi localization]
GO:0070062 [extracellular exosome]
GO:0090168 [Golgi reassembly]
Show all
 332 aa
37.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.