Fields »
ABOUT
HELP
BLOG
ID2

GENERAL INFORMATION

Gene name

 ID2

Gene description

 Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

Protein class

 Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (parathyroid gland)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ID2 (HGNC Symbol)

Synonyms

 bHLHb26, GIG8

Description

 Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]

Chromosome

 2

Cytoband

 p25.1

Chromosome location (bp)

 8678845 - 8684453

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115738 (version 83.38)

Entrez gene

 3398

UniProt

 Q02363 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02363

Antibodypedia

 ID2 antibodies

PROTEIN BROWSER
ID2-001
ID2-002
ID2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ID2-001
ENSP00000234091
ENST00000234091
Q02363 [Direct mapping]
DNA-binding protein inhibitor ID-2
Q53T66 [Target identity:100%; Query identity:100%]
Cell growth-inhibiting gene 8; Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, isoform CRA_a; Putative uncharacterized protein ID2; cDNA, FLJ92261, highly similar to Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2), mRNA
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001656 [metanephros development]
GO:0001779 [natural killer cell differentiation]
GO:0002521 [leukocyte differentiation]
GO:0003149 [membranous septum morphogenesis]
GO:0003166 [bundle of His development]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0007507 [heart development]
GO:0007623 [circadian rhythm]
GO:0009649 [entrainment of circadian clock]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0014003 [oligodendrocyte development]
GO:0015630 [microtubule cytoskeleton]
GO:0019216 [regulation of lipid metabolic process]
GO:0021772 [olfactory bulb development]
GO:0032922 [circadian regulation of gene expression]
GO:0033598 [mammary gland epithelial cell proliferation]
GO:0042752 [regulation of circadian rhythm]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043234 [protein complex]
GO:0043353 [enucleate erythrocyte differentiation]
GO:0043392 [negative regulation of DNA binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044325 [ion channel binding]
GO:0045475 [locomotor rhythm]
GO:0045578 [negative regulation of B cell differentiation]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045777 [positive regulation of blood pressure]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
GO:0048468 [cell development]
GO:0048469 [cell maturation]
GO:0048541 [Peyer's patch development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0048663 [neuron fate commitment]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0048715 [negative regulation of oligodendrocyte differentiation]
GO:0060612 [adipose tissue development]
GO:0060749 [mammary gland alveolus development]
GO:0061030 [epithelial cell differentiation involved in mammary gland alveolus development]
GO:0061031 [endodermal digestive tract morphogenesis]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071285 [cellular response to lithium ion]
GO:0071931 [positive regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0090398 [cellular senescence]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
GO:2000178 [negative regulation of neural precursor cell proliferation]
Show all
 134 aa
14.9 kDa 		No 0
ID2-002
ENSP00000385465
ENST00000331129
Q02363 [Direct mapping]
DNA-binding protein inhibitor ID-2
Q53T66 [Target identity:100%; Query identity:100%]
Cell growth-inhibiting gene 8; Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, isoform CRA_a; Putative uncharacterized protein ID2; cDNA, FLJ92261, highly similar to Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2), mRNA
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0019216 [regulation of lipid metabolic process]
GO:0032922 [circadian regulation of gene expression]
GO:0033598 [mammary gland epithelial cell proliferation]
GO:0042752 [regulation of circadian rhythm]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044325 [ion channel binding]
GO:0045475 [locomotor rhythm]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045777 [positive regulation of blood pressure]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0048663 [neuron fate commitment]
GO:0060749 [mammary gland alveolus development]
GO:0061030 [epithelial cell differentiation involved in mammary gland alveolus development]
GO:0061031 [endodermal digestive tract morphogenesis]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071931 [positive regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0090398 [cellular senescence]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
GO:2000178 [negative regulation of neural precursor cell proliferation]
Show all
 134 aa
14.9 kDa 		No 0
ID2-201
ENSP00000379585
ENST00000396290
Q02363 [Direct mapping]
DNA-binding protein inhibitor ID-2
Q53T66 [Target identity:100%; Query identity:100%]
Cell growth-inhibiting gene 8; Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, isoform CRA_a; Putative uncharacterized protein ID2; cDNA, FLJ92261, highly similar to Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2), mRNA
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0019216 [regulation of lipid metabolic process]
GO:0032922 [circadian regulation of gene expression]
GO:0033598 [mammary gland epithelial cell proliferation]
GO:0042752 [regulation of circadian rhythm]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044325 [ion channel binding]
GO:0045475 [locomotor rhythm]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045777 [positive regulation of blood pressure]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0048663 [neuron fate commitment]
GO:0060749 [mammary gland alveolus development]
GO:0061030 [epithelial cell differentiation involved in mammary gland alveolus development]
GO:0061031 [endodermal digestive tract morphogenesis]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071931 [positive regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0090398 [cellular senescence]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
GO:2000178 [negative regulation of neural precursor cell proliferation]
Show all
 134 aa
14.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.