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Papillary adenocarcinomas of thyroid and several colorectal cancers displayed moderate to strong cytoplasmic positivity. Many squamous cell carcinomas, pancreatic and renal cancers along with a few ovarian and stomach cancers were moderately stained. Remaining malignant cells were weakly stained or negative.
GENE INFORMATION
Gene name
HPCAL1 (HGNC Symbol)
Synonyms
BDR1, HLP2, VILIP-3
Description
Hippocalcin-like 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2012]