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PRKD3

CANCER ATLAS

Gene description

 Protein kinase D3

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029529

GENE INFORMATION

Gene name

 PRKD3 (HGNC Symbol)

Synonyms

 EPK2, PRKCN

Description

 Protein kinase D3 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]

Chromosome

 2

Cytoband

 p22.2

Chromosome location (bp)

 37250502 - 37324808

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115825 (version 83.38)

Entrez gene

 23683

UniProt

 O94806 (UniProt - Evidence at protein level)

neXtProt

 NX_O94806

Antibodypedia

 PRKD3 antibodies

PROTEIN BROWSER
PRKD3-001
PRKD3-004
PRKD3-007
PRKD3-008
PRKD3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKD3-001
ENSP00000368356
ENST00000379066
O94806 [Direct mapping]
Serine/threonine-protein kinase D3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
 890 aa
100.5 kDa 		No 0
PRKD3-004
ENSP00000401839
ENST00000443187
C9JKP8 [Direct mapping]
Serine/threonine-protein kinase D3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004697 [protein kinase C activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
 181 aa
20.7 kDa 		No 0
PRKD3-007
ENSP00000398743
ENST00000443977
H7C172 [Direct mapping]
Serine/threonine-protein kinase D3
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 173 aa
18.9 kDa 		No 0
PRKD3-008
ENSP00000399540
ENST00000452104
H0Y5M6 [Direct mapping]
Serine/threonine-protein kinase D3
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 185 aa
20.6 kDa 		No 0
PRKD3-201
ENSP00000234179
ENST00000234179
O94806 [Direct mapping]
Serine/threonine-protein kinase D3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
 890 aa
100.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.