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ORC4

CANCER ATLAS

Gene description

 Origin recognition complex, subunit 4

Protein class

 Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB015124

GENE INFORMATION

Gene name

 ORC4 (HGNC Symbol)

Synonyms

 HsORC4, ORC4L, Orc4p

Description

 Origin recognition complex, subunit 4 (HGNC Symbol)

Entrez gene summary

 The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010]

Chromosome

 2

Cytoband

 q23.1

Chromosome location (bp)

 147930397 - 148021604

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115947 (version 83.38)

Entrez gene

 5000

UniProt

 O43929 (UniProt - Evidence at protein level)

neXtProt

 NX_O43929

Antibodypedia

 ORC4 antibodies

PROTEIN BROWSER
ORC4-001
ORC4-002
ORC4-003
ORC4-006
ORC4-201
ORC4-202
ORC4-203
ORC4-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ORC4-001
ENSP00000376597
ENST00000392857
O43929 [Direct mapping]
Origin recognition complex subunit 4
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000278 [mitotic cell cycle]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000808 [origin recognition complex]
GO:0003677 [DNA binding]
GO:0003688 [DNA replication origin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005664 [nuclear origin of replication recognition complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006260 [DNA replication]
GO:0006270 [DNA replication initiation]
GO:0015629 [actin cytoskeleton]
Show all
 436 aa
50.4 kDa 		No 0
ORC4-002
ENSP00000413939
ENST00000416719
Q53SE3 [Direct mapping]
Origin recognition complex subunit 4; Putative uncharacterized protein ORC4L
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
Show all
 145 aa
16.4 kDa 		No 0
ORC4-003
ENSP00000403105
ENST00000440042
C9JGH7 [Direct mapping]
Origin recognition complex subunit 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
Show all
 127 aa
14.4 kDa 		No 0
ORC4-006
ENSP00000391484
ENST00000457954
C9J2X8 [Direct mapping]
Origin recognition complex subunit 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
Show all
 128 aa
14.5 kDa 		No 0
ORC4-201
ENSP00000264169
ENST00000264169
O43929 [Direct mapping]
Origin recognition complex subunit 4
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000278 [mitotic cell cycle]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000808 [origin recognition complex]
GO:0003677 [DNA binding]
GO:0003688 [DNA replication origin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005664 [nuclear origin of replication recognition complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006260 [DNA replication]
GO:0006270 [DNA replication initiation]
GO:0015629 [actin cytoskeleton]
Show all
 436 aa
50.4 kDa 		No 0
ORC4-202
ENSP00000441953
ENST00000535373
O43929 [Direct mapping]
Origin recognition complex subunit 4
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000278 [mitotic cell cycle]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000808 [origin recognition complex]
GO:0003677 [DNA binding]
GO:0003688 [DNA replication origin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005664 [nuclear origin of replication recognition complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006260 [DNA replication]
GO:0006270 [DNA replication initiation]
GO:0015629 [actin cytoskeleton]
Show all
 436 aa
50.4 kDa 		No 0
ORC4-203
ENSP00000441502
ENST00000536575
O43929 [Direct mapping]
Origin recognition complex subunit 4
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000278 [mitotic cell cycle]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000808 [origin recognition complex]
GO:0003677 [DNA binding]
GO:0003688 [DNA replication origin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005664 [nuclear origin of replication recognition complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006260 [DNA replication]
GO:0006270 [DNA replication initiation]
GO:0015629 [actin cytoskeleton]
Show all
 352 aa
40.9 kDa 		No 0
ORC4-204
ENSP00000438326
ENST00000540442
O43929 [Direct mapping]
Origin recognition complex subunit 4
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000278 [mitotic cell cycle]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000808 [origin recognition complex]
GO:0003677 [DNA binding]
GO:0003688 [DNA replication origin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005664 [nuclear origin of replication recognition complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006260 [DNA replication]
GO:0006270 [DNA replication initiation]
GO:0015629 [actin cytoskeleton]
Show all
 362 aa
42 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.