Cell atlas - AAK1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

AAK1

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	AAK1
Gene description	AP2 associated kinase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)
Additional location	In addition localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA017931 , HPA020289
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the cytosol.

Main location

Plasma membrane (supported)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017931	A-431	Cytosol
	HPA017931	U-2 OS	Cytosol
	HPA017931	U-251 MG	Plasma membrane
	HPA020289	A-431	Plasma membrane
	HPA020289	A-431	Cytosol
	HPA020289	U-2 OS	Plasma membrane
	HPA020289	U-2 OS	Cytosol

GENE INFORMATION
Gene name	AAK1 (HGNC Symbol)
Synonyms	DKFZp686K16132, KIAA1048
Description	AP2 associated kinase 1 (HGNC Symbol)
Entrez gene summary	Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p13.3
Chromosome location (bp)	69457997 - 69674349
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115977 (version 83.38)
Entrez gene	22848
UniProt	Q2M2I8 (UniProt - Evidence at protein level)
neXtProt	NX_Q2M2I8
Antibodypedia	AAK1 antibodies

PROTEIN BROWSER

AAK1-001	AAK1-002	AAK1-011	AAK1-012	AAK1-013	AAK1-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AAK1-001 ENSP00000386456 ENST00000409085	Q2M2I8 [Direct mapping] AP2-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005112 [Notch binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005905 [coated pit] GO:0006468 [protein phosphorylation] GO:0006897 [endocytosis] GO:0019897 [extrinsic component of plasma membrane] GO:0030136 [clathrin-coated vesicle] GO:0031252 [cell leading edge] GO:0032880 [regulation of protein localization] GO:0035612 [AP-2 adaptor complex binding] GO:0043195 [terminal bouton] GO:0045747 [positive regulation of Notch signaling pathway] GO:0046777 [protein autophosphorylation] GO:0050821 [protein stabilization] GO:2000369 [regulation of clathrin-mediated endocytosis] Show all	961 aa 103.9 kDa	No	0
AAK1-002 ENSP00000385181 ENST00000406297	Q2M2I8 [Direct mapping] AP2-associated protein kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005112 [Notch binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005905 [coated pit] GO:0006468 [protein phosphorylation] GO:0006897 [endocytosis] GO:0019897 [extrinsic component of plasma membrane] GO:0030136 [clathrin-coated vesicle] GO:0031252 [cell leading edge] GO:0032880 [regulation of protein localization] GO:0035612 [AP-2 adaptor complex binding] GO:0043195 [terminal bouton] GO:0045747 [positive regulation of Notch signaling pathway] GO:0046777 [protein autophosphorylation] GO:0050821 [protein stabilization] GO:2000369 [regulation of clathrin-mediated endocytosis] Show all	863 aa 93.6 kDa	No	0
AAK1-011 ENSP00000386342 ENST00000409068	E9PG46 [Direct mapping] AP2-associated protein kinase 1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	674 aa 73.8 kDa	No	0
AAK1-012 ENSP00000485350 ENST00000606389	A0A096LP25 [Direct mapping] AP2-associated protein kinase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		511 aa 54.4 kDa	No	0
AAK1-013 ENSP00000485296 ENST00000623317	A0A096LNZ0 [Direct mapping] AP2-associated protein kinase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		340 aa 36.4 kDa	No	0
AAK1-014 ENSP00000485409 ENST00000624900	A0A096LP60 [Direct mapping] AP2-associated protein kinase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		99 aa 10.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.