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Most testicular and colorectal cancers showed strong nuclear staining. Several malignant lymphomas, lung and urothelial cancers displayed moderate to strong nuclear staining. Remaining malignancies were weakly stained or negative.
GENE INFORMATION
Gene name
ARID3A (HGNC Symbol)
Synonyms
BRIGHT, DRIL1
Description
AT rich interactive domain 3A (BRIGHT-like) (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]
Q99856 [Direct mapping] AT-rich interactive domain-containing protein 3A
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Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0042803 [protein homodimerization activity] GO:0045121 [membrane raft] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
