Tissue expression of VAX2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	VAX2
Gene description	Ventral anterior homeobox 2
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Tissue enhanced (cerebellum)
FANTOM5:	Tissue enhanced (retina, cerebellum)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (retina, cerebellum)

GENE INFORMATION
Gene name	VAX2 (HGNC Symbol)
Synonyms	DRES93
Description	Ventral anterior homeobox 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a homeobox protein and is almost exclusively expressed in the ventral portion of the retina during development. In mouse studies, this gene was found to be required for the correct formation of the optic fissure and other aspects of retinal development. [provided by RefSeq, Sep 2008]
Chromosome	2
Cytoband	p13.3
Chromosome location (bp)	70900590 - 70933446
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116035 (version 83.38)
Entrez gene	25806
UniProt	Q9UIW0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UIW0
Antibodypedia	VAX2 antibodies

PROTEIN BROWSER

VAX2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VAX2-001 ENSP00000234392 ENST00000234392	Q9UIW0 [Direct mapping] Ventral anterior homeobox 2 F1T0K5 [Target identity:100%; Query identity:100%] Ventral anterior homeobox 2 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001162 [RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007398 [ectoderm development] GO:0007409 [axonogenesis] GO:0007601 [visual perception] GO:0009950 [dorsal/ventral axis specification] GO:0016055 [Wnt signaling pathway] GO:0030900 [forebrain development] GO:0031490 [chromatin DNA binding] GO:0043010 [camera-type eye development] GO:0043565 [sequence-specific DNA binding] GO:0048048 [embryonic eye morphogenesis] GO:0060041 [retina development in camera-type eye] Show all	290 aa 30.9 kDa	No	0