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ATP6V1B1

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GENERAL INFORMATION

Gene name

 ATP6V1B1

Gene description

 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus & nuclear membrane.

RNA cell category

 Group enriched (SK-BR-3, BEWO, HaCaT)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved), Nuclear membrane (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA031847
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SK-BR-3, BEWO, HaCaT)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus & nuclear membrane.

Main location

 Nucleus (approved), Nuclear membrane (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA031847 HaCaT Nucleus Intensity
Nuclear membrane Intensity
HPA031847 SH-SY5Y Nucleus Intensity
Nuclear membrane Intensity
HPA031847 U-2 OS Nucleus Intensity
Nuclear membrane Intensity

GENE INFORMATION

Gene name

 ATP6V1B1 (HGNC Symbol)

Synonyms

 ATP6B1, RTA1B, VATB, Vma2, VPP3

Description

 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p13.3

Chromosome location (bp)

 70935882 - 70965406

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116039 (version 83.38)

Entrez gene

 525

UniProt

 P15313 (UniProt - Evidence at protein level)

neXtProt

 NX_P15313

Antibodypedia

 ATP6V1B1 antibodies

PROTEIN BROWSER
ATP6V1B1-001
ATP6V1B1-005
ATP6V1B1-006
ATP6V1B1-007
ATP6V1B1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP6V1B1-001
ENSP00000234396
ENST00000234396
P15313 [Direct mapping]
V-type proton ATPase subunit B, kidney isoform
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005902 [microvillus]
GO:0006879 [cellular iron ion homeostasis]
GO:0006885 [regulation of pH]
GO:0007588 [excretion]
GO:0007605 [sensory perception of sound]
GO:0008286 [insulin receptor signaling pathway]
GO:0012505 [endomembrane system]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0032403 [protein complex binding]
GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain]
GO:0033180 [proton-transporting V-type ATPase, V1 domain]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0042472 [inner ear morphogenesis]
GO:0045851 [pH reduction]
GO:0046034 [ATP metabolic process]
GO:0055074 [calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0090382 [phagosome maturation]
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 513 aa
56.8 kDa 		No 0
ATP6V1B1-005
ENSP00000388353
ENST00000412314
C9JL73 [Direct mapping]
V-type proton ATPase subunit B, kidney isoform
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain]
GO:0033180 [proton-transporting V-type ATPase, V1 domain]
GO:0046034 [ATP metabolic process]
Show all
 496 aa
55.1 kDa 		No 0
ATP6V1B1-006
ENSP00000387599
ENST00000432098
C9JTN0 [Direct mapping]
V-type proton ATPase subunit B, kidney isoform
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 74 aa
8 kDa 		No 0
ATP6V1B1-007
ENSP00000408361
ENST00000454446
C9JNS9 [Direct mapping]
V-type proton ATPase subunit B, kidney isoform
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0015992 [proton transport]
GO:0046034 [ATP metabolic process]
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 249 aa
26.7 kDa 		No 0
ATP6V1B1-010
ENSP00000407840
ENST00000433895
C9JZ02 [Direct mapping]
V-type proton ATPase subunit B, kidney isoform
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain]
Show all
 118 aa
13.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.