Cell atlas - PLEKHA3 - The Human Protein Atlas

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PLEKHA3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	PLEKHA3
Gene description	Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA034496 , HPA034497
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ASSAYS

RNA expression

Human cells

Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (validated)


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Antibody	Cell line	Location
HPA034496	A-431	Golgi apparatus
HPA034496	U-2 OS	Golgi apparatus
HPA034496	U-251 MG	Golgi apparatus
HPA034497	A-431	Golgi apparatus
HPA034497	U-2 OS	Golgi apparatus
HPA034497	U-251 MG	Golgi apparatus

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA034496	U-2 OS	Image	Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) for a refined protein localization within the Golgi apparatus in U-2 OS cells. PLEKHA3 localizes to the Golgi apparatus, but not to the cis-Golgi compartment.
	HPA034497	U-2 OS	Image	Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) for a refined protein localization within the Golgi apparatus in U-2 OS cells. PLEKHA3 localizes to the Golgi apparatus, but not to the cis-Golgi compartment.

GENE INFORMATION
Gene name	PLEKHA3 (HGNC Symbol)
Synonyms	FAPP1
Description	Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q31.2
Chromosome location (bp)	178480468 - 178516462
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116095 (version 83.38)
Entrez gene	65977
UniProt	Q9HB20 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HB20
Antibodypedia	PLEKHA3 antibodies

PROTEIN BROWSER

PLEKHA3-001	PLEKHA3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLEKHA3-001 ENSP00000234453 ENST00000234453	Q9HB20 [Direct mapping] Pleckstrin homology domain-containing family A member 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005543 [phospholipid binding] GO:0005545 [1-phosphatidylinositol binding] GO:0005575 [cellular_component] GO:0005794 [Golgi apparatus] GO:0008150 [biological_process] GO:0016020 [membrane] Show all	300 aa 33.9 kDa	No	0
PLEKHA3-004 ENSP00000396136 ENST00000421187	H7C0Q0 [Direct mapping] Pleckstrin homology domain-containing family A member 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		114 aa 13 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.