Expression of NPHS2 in cancer - Summary

CANCER ATLAS

Gene description

Nephrosis 2, idiopathic, steroid-resistant (podocin)

Protein class

Disease related genes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA049486	CAB037267

GENE INFORMATION
Gene name	NPHS2 (HGNC Symbol)
Synonyms	PDCN, SRN1
Description	Nephrosis 2, idiopathic, steroid-resistant (podocin) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that plays a role in the regulation of glomerular permeability. Mutations in this gene cause steroid-resistant nephrotic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	1
Cytoband	q25.2
Chromosome location (bp)	179550539 - 179575952
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116218 (version 83.38)
Entrez gene	7827
UniProt	Q9NP85 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NP85
Antibodypedia	NPHS2 antibodies

PROTEIN BROWSER

NPHS2-001	NPHS2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPHS2-001 ENSP00000356587 ENST00000367615	Q9NP85 [Direct mapping] Podocin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0007588 [excretion] GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane] GO:0031532 [actin cytoskeleton reorganization] GO:0036057 [slit diaphragm] GO:0043234 [protein complex] GO:0045121 [membrane raft] GO:0070062 [extracellular exosome] GO:0072249 [metanephric glomerular visceral epithelial cell development] Show all	383 aa 42.2 kDa	No	1
NPHS2-002 ENSP00000356588 ENST00000367616	Q9NP85 [Direct mapping] Podocin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0007588 [excretion] GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane] GO:0031532 [actin cytoskeleton reorganization] GO:0036057 [slit diaphragm] GO:0043234 [protein complex] GO:0045121 [membrane raft] GO:0070062 [extracellular exosome] GO:0072249 [metanephric glomerular visceral epithelial cell development] Show all	315 aa 34.4 kDa	No	1