Cell atlas - RPL22 - The Human Protein Atlas

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RPL22

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	RPL22
Gene description	Ribosomal protein L22
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins Ribosomal proteins
Predicted localization	Intracellular
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	RPL22 (HGNC Symbol)
Synonyms	EAP, L22
Description	Ribosomal protein L22 (HGNC Symbol)
Entrez gene summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.31
Chromosome location (bp)	6181269 - 6209389
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116251 (version 83.38)
Entrez gene	6146
UniProt	P35268 (UniProt - Evidence at protein level)
neXtProt	NX_P35268
Antibodypedia	RPL22 antibodies

PROTEIN BROWSER

RPL22-001	RPL22-002	RPL22-004	RPL22-005	RPL22-006	RPL22-007	RPL22-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPL22-001 ENSP00000346088 ENST00000234875	P35268 [Direct mapping] 60S ribosomal protein L22 Show all	Ribosomal proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0002181 [cytoplasmic translation] GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0005925 [focal adhesion] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006414 [translational elongation] GO:0006415 [translational termination] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0008201 [heparin binding] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0022625 [cytosolic large ribosomal subunit] GO:0030529 [ribonucleoprotein complex] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0046632 [alpha-beta T cell differentiation] GO:0070062 [extracellular exosome] Show all	128 aa 14.8 kDa	No	0
RPL22-002 ENSP00000468274 ENST00000497965	K7ERI7 [Direct mapping] 60S ribosomal protein L22; Ribosomal protein L22, isoform CRA_b Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	95 aa 11.2 kDa	No	0
RPL22-004 ENSP00000465763 ENST00000484532	K7EKS7 [Direct mapping] 60S ribosomal protein L22 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	53 aa 5.7 kDa	No	0
RPL22-005 ENSP00000466013 ENST00000465387	K7ELC4 [Direct mapping] 60S ribosomal protein L22 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	79 aa 9.1 kDa	No	0
RPL22-006 ENSP00000465313 ENST00000465335	K7EJT5 [Direct mapping] 60S ribosomal protein L22 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	47 aa 5.1 kDa	No	0
RPL22-007 ENSP00000466502 ENST00000471204	K7EMH1 [Direct mapping] 60S ribosomal protein L22 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	89 aa 10.4 kDa	No	0
RPL22-008 ENSP00000467247 ENST00000462296	K7EP65 [Direct mapping] 60S ribosomal protein L22 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	48 aa 5.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.