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Weak to moderate cytoplasmic staining in all malignant tissues.
GENE INFORMATION
Gene name
PARK7 (HGNC Symbol)
Synonyms
DJ-1, DJ1
Description
Parkinson protein 7 (HGNC Symbol)
Entrez gene summary
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Q99497 [Direct mapping] Protein deglycase DJ-1 V9HWC2 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 67p
Show all
Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0001963 [synaptic transmission, dopaminergic] GO:0003713 [transcription coactivator activity] GO:0003729 [mRNA binding] GO:0005102 [receptor binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005758 [mitochondrial intermembrane space] GO:0005759 [mitochondrial matrix] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006469 [negative regulation of protein kinase activity] GO:0006508 [proteolysis] GO:0006517 [protein deglycosylation] GO:0006914 [autophagy] GO:0006954 [inflammatory response] GO:0006979 [response to oxidative stress] GO:0007005 [mitochondrion organization] GO:0007265 [Ras protein signal transduction] GO:0007338 [single fertilization] GO:0008134 [transcription factor binding] GO:0008233 [peptidase activity] GO:0008344 [adult locomotory behavior] GO:0010273 [detoxification of copper ion] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016532 [superoxide dismutase copper chaperone activity] GO:0016605 [PML body] GO:0016684 [oxidoreductase activity, acting on peroxide as acceptor] GO:0018323 [enzyme active site formation via L-cysteine sulfinic acid] GO:0019172 [glyoxalase III activity] GO:0019243 [methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione] GO:0019249 [lactate biosynthetic process] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019955 [cytokine binding] GO:0030424 [axon] GO:0031397 [negative regulation of protein ubiquitination] GO:0032091 [negative regulation of protein binding] GO:0032148 [activation of protein kinase B activity] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032757 [positive regulation of interleukin-8 production] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0033234 [negative regulation of protein sumoylation] GO:0034599 [cellular response to oxidative stress] GO:0034614 [cellular response to reactive oxygen species] GO:0036470 [tyrosine 3-monooxygenase activator activity] GO:0036471 [cellular response to glyoxal] GO:0036478 [L-dopa decarboxylase activator activity] GO:0042177 [negative regulation of protein catabolic process] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0042743 [hydrogen peroxide metabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043005 [neuron projection] GO:0043066 [negative regulation of apoptotic process] GO:0043523 [regulation of neuron apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044297 [cell body] GO:0044388 [small protein activating enzyme binding] GO:0044390 [ubiquitin-like protein conjugating enzyme binding] GO:0045121 [membrane raft] GO:0045340 [mercury ion binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046295 [glycolate biosynthetic process] GO:0046826 [negative regulation of protein export from nucleus] GO:0050681 [androgen receptor binding] GO:0050727 [regulation of inflammatory response] GO:0050787 [detoxification of mercury ion] GO:0050821 [protein stabilization] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051444 [negative regulation of ubiquitin-protein transferase activity] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051881 [regulation of mitochondrial membrane potential] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051899 [membrane depolarization] GO:0051920 [peroxiredoxin activity] GO:0060081 [membrane hyperpolarization] GO:0060548 [negative regulation of cell death] GO:0060765 [regulation of androgen receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0070491 [repressing transcription factor binding] GO:0090073 [positive regulation of protein homodimerization activity] GO:0097110 [scaffold protein binding] GO:1900182 [positive regulation of protein localization to nucleus] GO:1901215 [negative regulation of neuron death] GO:1901671 [positive regulation of superoxide dismutase activity] GO:1901984 [negative regulation of protein acetylation] GO:1902177 [positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1902903 [regulation of fibril organization] GO:1902958 [positive regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903073 [negative regulation of death-inducing signaling complex assembly] GO:1903094 [negative regulation of protein K48-linked deubiquitination] GO:1903122 [negative regulation of TRAIL-activated apoptotic signaling pathway] GO:1903135 [cupric ion binding] GO:1903136 [cuprous ion binding] GO:1903168 [positive regulation of pyrroline-5-carboxylate reductase activity] GO:1903178 [positive regulation of tyrosine 3-monooxygenase activity] GO:1903181 [positive regulation of dopamine biosynthetic process] GO:1903190 [glyoxal catabolic process] GO:1903197 [positive regulation of L-dopa biosynthetic process] GO:1903200 [positive regulation of L-dopa decarboxylase activity] GO:1903202 [negative regulation of oxidative stress-induced cell death] GO:1903204 [negative regulation of oxidative stress-induced neuron death] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:1903208 [negative regulation of hydrogen peroxide-induced neuron death] GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway] GO:1903384 [negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway] GO:1903428 [positive regulation of reactive oxygen species biosynthetic process] GO:1903599 [positive regulation of mitophagy] GO:1990381 [ubiquitin-specific protease binding] GO:1990422 [glyoxalase (glycolic acid-forming) activity] GO:2000157 [negative regulation of ubiquitin-specific protease activity] GO:2000277 [positive regulation of oxidative phosphorylation uncoupler activity] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000825 [positive regulation of androgen receptor activity] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Q99497 [Direct mapping] Protein deglycase DJ-1 V9HWC2 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 67p
Show all
Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0003713 [transcription coactivator activity] GO:0003729 [mRNA binding] GO:0005102 [receptor binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006469 [negative regulation of protein kinase activity] GO:0006508 [proteolysis] GO:0006517 [protein deglycosylation] GO:0006914 [autophagy] GO:0006954 [inflammatory response] GO:0007005 [mitochondrion organization] GO:0007265 [Ras protein signal transduction] GO:0007338 [single fertilization] GO:0008134 [transcription factor binding] GO:0008233 [peptidase activity] GO:0010273 [detoxification of copper ion] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016532 [superoxide dismutase copper chaperone activity] GO:0016605 [PML body] GO:0016684 [oxidoreductase activity, acting on peroxide as acceptor] GO:0019172 [glyoxalase III activity] GO:0019243 [methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione] GO:0019249 [lactate biosynthetic process] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019955 [cytokine binding] GO:0030424 [axon] GO:0031397 [negative regulation of protein ubiquitination] GO:0032091 [negative regulation of protein binding] GO:0032148 [activation of protein kinase B activity] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032757 [positive regulation of interleukin-8 production] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0033234 [negative regulation of protein sumoylation] GO:0034599 [cellular response to oxidative stress] GO:0036470 [tyrosine 3-monooxygenase activator activity] GO:0036471 [cellular response to glyoxal] GO:0036478 [L-dopa decarboxylase activator activity] GO:0042743 [hydrogen peroxide metabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043523 [regulation of neuron apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044388 [small protein activating enzyme binding] GO:0044390 [ubiquitin-like protein conjugating enzyme binding] GO:0045121 [membrane raft] GO:0045340 [mercury ion binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046295 [glycolate biosynthetic process] GO:0046826 [negative regulation of protein export from nucleus] GO:0050681 [androgen receptor binding] GO:0050727 [regulation of inflammatory response] GO:0050787 [detoxification of mercury ion] GO:0050821 [protein stabilization] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051444 [negative regulation of ubiquitin-protein transferase activity] GO:0051881 [regulation of mitochondrial membrane potential] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060548 [negative regulation of cell death] GO:0060765 [regulation of androgen receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0070491 [repressing transcription factor binding] GO:0090073 [positive regulation of protein homodimerization activity] GO:0097110 [scaffold protein binding] GO:1900182 [positive regulation of protein localization to nucleus] GO:1901215 [negative regulation of neuron death] GO:1901671 [positive regulation of superoxide dismutase activity] GO:1901984 [negative regulation of protein acetylation] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1902903 [regulation of fibril organization] GO:1902958 [positive regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903073 [negative regulation of death-inducing signaling complex assembly] GO:1903094 [negative regulation of protein K48-linked deubiquitination] GO:1903122 [negative regulation of TRAIL-activated apoptotic signaling pathway] GO:1903135 [cupric ion binding] GO:1903136 [cuprous ion binding] GO:1903168 [positive regulation of pyrroline-5-carboxylate reductase activity] GO:1903178 [positive regulation of tyrosine 3-monooxygenase activity] GO:1903181 [positive regulation of dopamine biosynthetic process] GO:1903190 [glyoxal catabolic process] GO:1903197 [positive regulation of L-dopa biosynthetic process] GO:1903200 [positive regulation of L-dopa decarboxylase activity] GO:1903202 [negative regulation of oxidative stress-induced cell death] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:1903208 [negative regulation of hydrogen peroxide-induced neuron death] GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway] GO:1903384 [negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway] GO:1903599 [positive regulation of mitophagy] GO:1990381 [ubiquitin-specific protease binding] GO:1990422 [glyoxalase (glycolic acid-forming) activity] GO:2000157 [negative regulation of ubiquitin-specific protease activity] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000825 [positive regulation of androgen receptor activity] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Q99497 [Direct mapping] Protein deglycase DJ-1 V9HWC2 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 67p
Show all
Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0003713 [transcription coactivator activity] GO:0003729 [mRNA binding] GO:0005102 [receptor binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006469 [negative regulation of protein kinase activity] GO:0006508 [proteolysis] GO:0006517 [protein deglycosylation] GO:0006914 [autophagy] GO:0006954 [inflammatory response] GO:0007005 [mitochondrion organization] GO:0007265 [Ras protein signal transduction] GO:0007338 [single fertilization] GO:0008134 [transcription factor binding] GO:0008233 [peptidase activity] GO:0010273 [detoxification of copper ion] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016532 [superoxide dismutase copper chaperone activity] GO:0016605 [PML body] GO:0016684 [oxidoreductase activity, acting on peroxide as acceptor] GO:0019172 [glyoxalase III activity] GO:0019243 [methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione] GO:0019249 [lactate biosynthetic process] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019955 [cytokine binding] GO:0030424 [axon] GO:0031397 [negative regulation of protein ubiquitination] GO:0032091 [negative regulation of protein binding] GO:0032148 [activation of protein kinase B activity] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032757 [positive regulation of interleukin-8 production] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0033234 [negative regulation of protein sumoylation] GO:0034599 [cellular response to oxidative stress] GO:0036470 [tyrosine 3-monooxygenase activator activity] GO:0036471 [cellular response to glyoxal] GO:0036478 [L-dopa decarboxylase activator activity] GO:0042743 [hydrogen peroxide metabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043523 [regulation of neuron apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044388 [small protein activating enzyme binding] GO:0044390 [ubiquitin-like protein conjugating enzyme binding] GO:0045121 [membrane raft] GO:0045340 [mercury ion binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046295 [glycolate biosynthetic process] GO:0046826 [negative regulation of protein export from nucleus] GO:0050681 [androgen receptor binding] GO:0050727 [regulation of inflammatory response] GO:0050787 [detoxification of mercury ion] GO:0050821 [protein stabilization] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051444 [negative regulation of ubiquitin-protein transferase activity] GO:0051881 [regulation of mitochondrial membrane potential] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060548 [negative regulation of cell death] GO:0060765 [regulation of androgen receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0070491 [repressing transcription factor binding] GO:0090073 [positive regulation of protein homodimerization activity] GO:0097110 [scaffold protein binding] GO:1900182 [positive regulation of protein localization to nucleus] GO:1901215 [negative regulation of neuron death] GO:1901671 [positive regulation of superoxide dismutase activity] GO:1901984 [negative regulation of protein acetylation] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1902903 [regulation of fibril organization] GO:1902958 [positive regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903073 [negative regulation of death-inducing signaling complex assembly] GO:1903094 [negative regulation of protein K48-linked deubiquitination] GO:1903122 [negative regulation of TRAIL-activated apoptotic signaling pathway] GO:1903135 [cupric ion binding] GO:1903136 [cuprous ion binding] GO:1903168 [positive regulation of pyrroline-5-carboxylate reductase activity] GO:1903178 [positive regulation of tyrosine 3-monooxygenase activity] GO:1903181 [positive regulation of dopamine biosynthetic process] GO:1903190 [glyoxal catabolic process] GO:1903197 [positive regulation of L-dopa biosynthetic process] GO:1903200 [positive regulation of L-dopa decarboxylase activity] GO:1903202 [negative regulation of oxidative stress-induced cell death] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:1903208 [negative regulation of hydrogen peroxide-induced neuron death] GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway] GO:1903384 [negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway] GO:1903599 [positive regulation of mitophagy] GO:1990381 [ubiquitin-specific protease binding] GO:1990422 [glyoxalase (glycolic acid-forming) activity] GO:2000157 [negative regulation of ubiquitin-specific protease activity] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000825 [positive regulation of androgen receptor activity] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Q99497 [Direct mapping] Protein deglycase DJ-1 V9HWC2 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 67p
Show all
Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0003713 [transcription coactivator activity] GO:0003729 [mRNA binding] GO:0005102 [receptor binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006469 [negative regulation of protein kinase activity] GO:0006508 [proteolysis] GO:0006517 [protein deglycosylation] GO:0006914 [autophagy] GO:0006954 [inflammatory response] GO:0007005 [mitochondrion organization] GO:0007265 [Ras protein signal transduction] GO:0007338 [single fertilization] GO:0008134 [transcription factor binding] GO:0008233 [peptidase activity] GO:0010273 [detoxification of copper ion] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016532 [superoxide dismutase copper chaperone activity] GO:0016605 [PML body] GO:0016684 [oxidoreductase activity, acting on peroxide as acceptor] GO:0019172 [glyoxalase III activity] GO:0019243 [methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione] GO:0019249 [lactate biosynthetic process] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019955 [cytokine binding] GO:0030424 [axon] GO:0031397 [negative regulation of protein ubiquitination] GO:0032091 [negative regulation of protein binding] GO:0032148 [activation of protein kinase B activity] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032757 [positive regulation of interleukin-8 production] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0033234 [negative regulation of protein sumoylation] GO:0034599 [cellular response to oxidative stress] GO:0036470 [tyrosine 3-monooxygenase activator activity] GO:0036471 [cellular response to glyoxal] GO:0036478 [L-dopa decarboxylase activator activity] GO:0042743 [hydrogen peroxide metabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043523 [regulation of neuron apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044388 [small protein activating enzyme binding] GO:0044390 [ubiquitin-like protein conjugating enzyme binding] GO:0045121 [membrane raft] GO:0045340 [mercury ion binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046295 [glycolate biosynthetic process] GO:0046826 [negative regulation of protein export from nucleus] GO:0050681 [androgen receptor binding] GO:0050727 [regulation of inflammatory response] GO:0050787 [detoxification of mercury ion] GO:0050821 [protein stabilization] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051444 [negative regulation of ubiquitin-protein transferase activity] GO:0051881 [regulation of mitochondrial membrane potential] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060548 [negative regulation of cell death] GO:0060765 [regulation of androgen receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0070491 [repressing transcription factor binding] GO:0090073 [positive regulation of protein homodimerization activity] GO:0097110 [scaffold protein binding] GO:1900182 [positive regulation of protein localization to nucleus] GO:1901215 [negative regulation of neuron death] GO:1901671 [positive regulation of superoxide dismutase activity] GO:1901984 [negative regulation of protein acetylation] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1902903 [regulation of fibril organization] GO:1902958 [positive regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903073 [negative regulation of death-inducing signaling complex assembly] GO:1903094 [negative regulation of protein K48-linked deubiquitination] GO:1903122 [negative regulation of TRAIL-activated apoptotic signaling pathway] GO:1903135 [cupric ion binding] GO:1903136 [cuprous ion binding] GO:1903168 [positive regulation of pyrroline-5-carboxylate reductase activity] GO:1903178 [positive regulation of tyrosine 3-monooxygenase activity] GO:1903181 [positive regulation of dopamine biosynthetic process] GO:1903190 [glyoxal catabolic process] GO:1903197 [positive regulation of L-dopa biosynthetic process] GO:1903200 [positive regulation of L-dopa decarboxylase activity] GO:1903202 [negative regulation of oxidative stress-induced cell death] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:1903208 [negative regulation of hydrogen peroxide-induced neuron death] GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway] GO:1903384 [negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway] GO:1903599 [positive regulation of mitophagy] GO:1990381 [ubiquitin-specific protease binding] GO:1990422 [glyoxalase (glycolic acid-forming) activity] GO:2000157 [negative regulation of ubiquitin-specific protease activity] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000825 [positive regulation of androgen receptor activity] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Q99497 [Direct mapping] Protein deglycase DJ-1 V9HWC2 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 67p
Show all
Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0003713 [transcription coactivator activity] GO:0003729 [mRNA binding] GO:0005102 [receptor binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006469 [negative regulation of protein kinase activity] GO:0006508 [proteolysis] GO:0006517 [protein deglycosylation] GO:0006914 [autophagy] GO:0006954 [inflammatory response] GO:0007005 [mitochondrion organization] GO:0007265 [Ras protein signal transduction] GO:0007338 [single fertilization] GO:0008134 [transcription factor binding] GO:0008233 [peptidase activity] GO:0010273 [detoxification of copper ion] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016532 [superoxide dismutase copper chaperone activity] GO:0016605 [PML body] GO:0016684 [oxidoreductase activity, acting on peroxide as acceptor] GO:0019172 [glyoxalase III activity] GO:0019243 [methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione] GO:0019249 [lactate biosynthetic process] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019955 [cytokine binding] GO:0030424 [axon] GO:0031397 [negative regulation of protein ubiquitination] GO:0032091 [negative regulation of protein binding] GO:0032148 [activation of protein kinase B activity] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032757 [positive regulation of interleukin-8 production] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0033234 [negative regulation of protein sumoylation] GO:0034599 [cellular response to oxidative stress] GO:0036470 [tyrosine 3-monooxygenase activator activity] GO:0036471 [cellular response to glyoxal] GO:0036478 [L-dopa decarboxylase activator activity] GO:0042743 [hydrogen peroxide metabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043523 [regulation of neuron apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044388 [small protein activating enzyme binding] GO:0044390 [ubiquitin-like protein conjugating enzyme binding] GO:0045121 [membrane raft] GO:0045340 [mercury ion binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046295 [glycolate biosynthetic process] GO:0046826 [negative regulation of protein export from nucleus] GO:0050681 [androgen receptor binding] GO:0050727 [regulation of inflammatory response] GO:0050787 [detoxification of mercury ion] GO:0050821 [protein stabilization] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051444 [negative regulation of ubiquitin-protein transferase activity] GO:0051881 [regulation of mitochondrial membrane potential] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060548 [negative regulation of cell death] GO:0060765 [regulation of androgen receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0070491 [repressing transcription factor binding] GO:0090073 [positive regulation of protein homodimerization activity] GO:0097110 [scaffold protein binding] GO:1900182 [positive regulation of protein localization to nucleus] GO:1901215 [negative regulation of neuron death] GO:1901671 [positive regulation of superoxide dismutase activity] GO:1901984 [negative regulation of protein acetylation] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1902903 [regulation of fibril organization] GO:1902958 [positive regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903073 [negative regulation of death-inducing signaling complex assembly] GO:1903094 [negative regulation of protein K48-linked deubiquitination] GO:1903122 [negative regulation of TRAIL-activated apoptotic signaling pathway] GO:1903135 [cupric ion binding] GO:1903136 [cuprous ion binding] GO:1903168 [positive regulation of pyrroline-5-carboxylate reductase activity] GO:1903178 [positive regulation of tyrosine 3-monooxygenase activity] GO:1903181 [positive regulation of dopamine biosynthetic process] GO:1903190 [glyoxal catabolic process] GO:1903197 [positive regulation of L-dopa biosynthetic process] GO:1903200 [positive regulation of L-dopa decarboxylase activity] GO:1903202 [negative regulation of oxidative stress-induced cell death] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:1903208 [negative regulation of hydrogen peroxide-induced neuron death] GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway] GO:1903384 [negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway] GO:1903599 [positive regulation of mitophagy] GO:1990381 [ubiquitin-specific protease binding] GO:1990422 [glyoxalase (glycolic acid-forming) activity] GO:2000157 [negative regulation of ubiquitin-specific protease activity] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000825 [positive regulation of androgen receptor activity] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]