Expression of ATP5F1 in cancer - Summary

CANCER ATLAS

Gene description

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1

Protein class

Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA046067	HPA057347

GENE INFORMATION
Gene name	ATP5F1
Synonyms
Description	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p13.2
Chromosome location (bp)	111448864 - 111462773
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116459 (version 83.38)
Entrez gene	515
UniProt	P24539 (UniProt - Evidence at protein level)
neXtProt	NX_P24539
Antibodypedia	ATP5F1 antibodies

PROTEIN BROWSER

ATP5F1-001	ATP5F1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP5F1-001 ENSP00000358737 ENST00000369722	P24539 [Direct mapping] ATP synthase F(0) complex subunit B1, mitochondrial Q08ET0 [Target identity:100%; Query identity:100%] Cell proliferation-inducing protein 47; HCG39985, isoform CRA_a; cDNA, FLJ94101, Homo sapiens ATP synthase, H+ transporting, mitochondrial F0complex, subunit b, isoform 1 (ATP5F1), mRNA Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000276 [mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005753 [mitochondrial proton-transporting ATP synthase complex] GO:0005759 [mitochondrial matrix] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0016020 [membrane] GO:0016887 [ATPase activity] GO:0021762 [substantia nigra development] GO:0022857 [transmembrane transporter activity] GO:0022904 [respiratory electron transport chain] GO:0042776 [mitochondrial ATP synthesis coupled proton transport] GO:0043209 [myelin sheath] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism] GO:0070062 [extracellular exosome] Show all	256 aa 28.9 kDa	Yes	0
ATP5F1-005 ENSP00000420366 ENST00000483994	Q5QNZ2 [Direct mapping] ATP synthase F(0) complex subunit B1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000276 [mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0016021 [integral component of membrane] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism] Show all	195 aa 22.3 kDa	No	2