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ARHGEF2

GENERAL INFORMATION

Gene name

 ARHGEF2

Gene description

 Rho/Rac guanine nucleotide exchange factor (GEF) 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression of varying intensities in several different tissue types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA043437
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ARHGEF2 (HGNC Symbol)

Synonyms

 GEF-H1, KIAA0651, LFP40, P40

Description

 Rho/Rac guanine nucleotide exchange factor (GEF) 2 (HGNC Symbol)

Entrez gene summary

 Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]

Chromosome

 1

Cytoband

 q22

Chromosome location (bp)

 155946851 - 156007070

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116584 (version 83.38)

Entrez gene

 9181

UniProt

 Q92974 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92974

Antibodypedia

 ARHGEF2 antibodies

PROTEIN BROWSER
«
ARHGEF2-001
ARHGEF2-002
ARHGEF2-003
ARHGEF2-004
ARHGEF2-005
ARHGEF2-007
ARHGEF2-010
ARHGEF2-012
ARHGEF2-017
ARHGEF2-018
ARHGEF2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGEF2-001
ENSP00000354837
ENST00000361247
Q92974 [Direct mapping]
Rho guanine nucleotide exchange factor 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000902 [cell morphogenesis]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005923 [bicellular tight junction]
GO:0005925 [focal adhesion]
GO:0006886 [intracellular protein transport]
GO:0007015 [actin filament organization]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0017048 [Rho GTPase binding]
GO:0030676 [Rac guanyl-nucleotide exchange factor activity]
GO:0031982 [vesicle]
GO:0032587 [ruffle membrane]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043198 [dendritic shaft]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050768 [negative regulation of neurogenesis]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051301 [cell division]
GO:0060546 [negative regulation of necroptotic process]
GO:0071225 [cellular response to muramyl dipeptide]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071474 [cellular hyperosmotic response]
GO:0097190 [apoptotic signaling pathway]
GO:0097481 [neuronal postsynaptic density]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902219 [negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress]
Show all
 986 aa
111.5 kDa 		No 0
ARHGEF2-002
ENSP00000314787
ENST00000313667
Q92974 [Direct mapping]
Rho guanine nucleotide exchange factor 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005923 [bicellular tight junction]
GO:0005925 [focal adhesion]
GO:0006886 [intracellular protein transport]
GO:0007015 [actin filament organization]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0017048 [Rho GTPase binding]
GO:0030676 [Rac guanyl-nucleotide exchange factor activity]
GO:0031982 [vesicle]
GO:0032587 [ruffle membrane]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051301 [cell division]
GO:0060546 [negative regulation of necroptotic process]
GO:0071225 [cellular response to muramyl dipeptide]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071474 [cellular hyperosmotic response]
GO:0097190 [apoptotic signaling pathway]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902219 [negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress]
Show all
 985 aa
111.5 kDa 		No 0
ARHGEF2-003
ENSP00000315325
ENST00000313695
Q92974 [Direct mapping]
Rho guanine nucleotide exchange factor 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005923 [bicellular tight junction]
GO:0005925 [focal adhesion]
GO:0006886 [intracellular protein transport]
GO:0007015 [actin filament organization]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0017048 [Rho GTPase binding]
GO:0030676 [Rac guanyl-nucleotide exchange factor activity]
GO:0031982 [vesicle]
GO:0032587 [ruffle membrane]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051301 [cell division]
GO:0060546 [negative regulation of necroptotic process]
GO:0071225 [cellular response to muramyl dipeptide]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071474 [cellular hyperosmotic response]
GO:0097190 [apoptotic signaling pathway]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902219 [negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress]
Show all
 958 aa
108.2 kDa 		No 0
ARHGEF2-004
ENSP00000476916
ENST00000462460
V9GYM8 [Direct mapping]
Rho guanine nucleotide exchange factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
Show all
 1031 aa
116.1 kDa 		No 0
ARHGEF2-005
ENSP00000476532
ENST00000495070
V9GY94 [Direct mapping]
Rho guanine nucleotide exchange factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 84 aa
9.1 kDa 		No 0
ARHGEF2-007
ENSP00000476689
ENST00000470541
V9GYF0 [Direct mapping]
Rho guanine nucleotide exchange factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 263 aa
29.4 kDa 		No 0
ARHGEF2-010
ENSP00000477299
ENST00000471589
V9GZ14 [Direct mapping]
Rho guanine nucleotide exchange factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 229 aa
25.7 kDa 		No 0
ARHGEF2-012
ENSP00000476724
ENST00000497907
V9GYG5 [Direct mapping]
Rho guanine nucleotide exchange factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0035556 [intracellular signal transduction]
Show all
 214 aa
23.9 kDa 		No 0
ARHGEF2-017
ENSP00000476518
ENST00000423422
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 7 aa
0.8 kDa 		No 0
ARHGEF2-018
ENSP00000476699
ENST00000609707
V9GYF5 [Direct mapping]
Rho guanine nucleotide exchange factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0035556 [intracellular signal transduction]
Show all
 178 aa
19.8 kDa 		No 0
ARHGEF2-201
ENSP00000357298
ENST00000368315
Q5VY93 [Direct mapping]
Rho guanine nucleotide exchange factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 264 aa
29 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.