Cell atlas - DNAJC6 - The Human Protein Atlas

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DNAJC6

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	DNAJC6
Gene description	DnaJ (Hsp40) homolog, subfamily C, member 6
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the plasma membrane & nucleoplasm.
RNA cell category	Cell line enhanced (HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Nucleoplasm (approved), Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA031182
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the plasma membrane & nucleoplasm.

Main location

Cytosol (approved)

Additional location

Nucleoplasm (approved), Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA031182	A-431	Plasma membrane
	HPA031182	A-431	Cytosol
	HPA031182	U-2 OS	Nucleoplasm
	HPA031182	U-2 OS	Cytosol
	HPA031182	U-251 MG	Nucleoplasm
			Nuclear bodies
			Cytosol

GENE INFORMATION
Gene name	DNAJC6 (HGNC Symbol)
Synonyms	KIAA0473, PARK19
Description	DnaJ (Hsp40) homolog, subfamily C, member 6 (HGNC Symbol)
Entrez gene summary	DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008]
Chromosome	1
Cytoband	p31.3
Chromosome location (bp)	65248219 - 65415869
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116675 (version 83.38)
Entrez gene	9829
UniProt	O75061 (UniProt - Evidence at protein level)
neXtProt	NX_O75061
Antibodypedia	DNAJC6 antibodies

PROTEIN BROWSER

DNAJC6-001	DNAJC6-002	DNAJC6-008	DNAJC6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNAJC6-001 ENSP00000378735 ENST00000395325	O75061 [Direct mapping] Putative tyrosine-protein phosphatase auxilin Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006892 [post-Golgi vesicle-mediated transport] GO:0017124 [SH3 domain binding] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0061024 [membrane organization] Show all	913 aa 100 kDa	No	0
DNAJC6-002 ENSP00000360108 ENST00000371069	O75061 [Direct mapping] Putative tyrosine-protein phosphatase auxilin Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006892 [post-Golgi vesicle-mediated transport] GO:0017124 [SH3 domain binding] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0045202 [synapse] GO:0061024 [membrane organization] GO:0072318 [clathrin coat disassembly] GO:0097481 [neuronal postsynaptic density] GO:2000369 [regulation of clathrin-mediated endocytosis] Show all	970 aa 105.7 kDa	No	0
DNAJC6-008 ENSP00000473821 ENST00000494710	S4R305 [Direct mapping] Putative tyrosine-protein phosphatase auxilin Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	516 aa 58.4 kDa	No	0
DNAJC6-201 ENSP00000263441 ENST00000263441	O75061 [Direct mapping] Putative tyrosine-protein phosphatase auxilin Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006892 [post-Golgi vesicle-mediated transport] GO:0017124 [SH3 domain binding] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0061024 [membrane organization] Show all	900 aa 98.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.