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Several lung and endometrial cancers displayed moderate to strong cytoplasmic and/or nuclear positivity. A majority of prostate, breast, urothelial, pancreatic and liver cancers showed moderate cytoplasmic and/or nuclear immunoreactivity. Remaining malignancies were weakly stained or negative.
GENE INFORMATION
Gene name
PRG4 (HGNC Symbol)
Synonyms
bG174L6.2, CACP, FLJ32635, HAPO, JCAP, MSF, SZP
Description
Proteoglycan 4 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]