Expression of MRPS15 in cancer - Summary

CANCER ATLAS

Gene description

Mitochondrial ribosomal protein S15

Protein class

Predicted intracellular proteins, Ribosomal proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA028100	HPA028134

GENE INFORMATION
Gene name	MRPS15 (HGNC Symbol)
Synonyms	FLJ11564
Description	Mitochondrial ribosomal protein S15 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 15q and 19q. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p34.3
Chromosome location (bp)	36455718 - 36464437
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116898 (version 83.38)
Entrez gene	64960
UniProt	P82914 (UniProt - Evidence at protein level)
neXtProt	NX_P82914
Antibodypedia	MRPS15 antibodies

PROTEIN BROWSER

MRPS15-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPS15-001 ENSP00000362208 ENST00000373116	P82914 [Direct mapping] 28S ribosomal protein S15, mitochondrial Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005761 [mitochondrial ribosome] GO:0005763 [mitochondrial small ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0031965 [nuclear membrane] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	257 aa 29.8 kDa	No	0