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GNPAT

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GENERAL INFORMATION

Gene name

 GNPAT

Gene description

 Glyceronephosphate O-acyltransferase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 GNPAT (HGNC Symbol)

Synonyms

 DAP-AT, DAPAT, DHAPAT

Description

 Glyceronephosphate O-acyltransferase (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme located in the peroxisomal membrane which is essential to the synthesis of ether phospholipids. Mutations in this gene are associated with rhizomelic chondrodysplasia punctata. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Chromosome

 1

Cytoband

 q42.2

Chromosome location (bp)

 231241207 - 231277973

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116906 (version 83.38)

Entrez gene

 8443

UniProt

 O15228 (UniProt - Evidence at protein level)

neXtProt

 NX_O15228

Antibodypedia

 GNPAT antibodies

PROTEIN BROWSER
GNPAT-001
GNPAT-002
GNPAT-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNPAT-001
ENSP00000355607
ENST00000366647
O15228 [Direct mapping]
Dihydroxyacetone phosphate acyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0005782 [peroxisomal matrix]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0007416 [synapse assembly]
GO:0007584 [response to nutrient]
GO:0008152 [metabolic process]
GO:0008374 [O-acyltransferase activity]
GO:0008611 [ether lipid biosynthetic process]
GO:0016020 [membrane]
GO:0016287 [glycerone-phosphate O-acyltransferase activity]
GO:0016290 [palmitoyl-CoA hydrolase activity]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0021587 [cerebellum morphogenesis]
GO:0030913 [paranodal junction assembly]
GO:0042493 [response to drug]
GO:0042552 [myelination]
GO:0042594 [response to starvation]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0061024 [membrane organization]
GO:0070542 [response to fatty acid]
Show all
 680 aa
77.2 kDa 		No 0
GNPAT-002
ENSP00000411640
ENST00000416000
Q5TBH8 [Direct mapping]
Dihydroxyacetone phosphate acyltransferase
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005777 [peroxisome]
GO:0008152 [metabolic process]
GO:0008611 [ether lipid biosynthetic process]
GO:0016287 [glycerone-phosphate O-acyltransferase activity]
GO:0016746 [transferase activity, transferring acyl groups]
Show all
 587 aa
67 kDa 		No 0
GNPAT-003
ENSP00000402811
ENST00000436239
Q5TBH6 [Direct mapping]
Dihydroxyacetone phosphate acyltransferase
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0008374 [O-acyltransferase activity]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0044255 [cellular lipid metabolic process]
Show all
 222 aa
25.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.