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BMP8B

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GENERAL INFORMATION

Gene name

 BMP8B

Gene description

 Bone morphogenetic protein 8b

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (THP-1, WM-115, U-266/84)

Protein evidence

 Evidence at transcript level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (THP-1, WM-115, U-266/84)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 BMP8B (HGNC Symbol)

Synonyms

 BMP8, OP-2

Description

 Bone morphogenetic protein 8b (HGNC Symbol)

Entrez gene summary

 The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p34.2

Chromosome location (bp)

 39757182 - 39788861

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000116985 (version 83.38)

Entrez gene

 656

UniProt

 P34820 (UniProt - Evidence at transcript level)

neXtProt

 NX_P34820

Antibodypedia

 BMP8B antibodies

PROTEIN BROWSER
BMP8B-001
BMP8B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BMP8B-001
ENSP00000361915
ENST00000372827
P34820 [Direct mapping]
Bone morphogenetic protein 8B
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
GO:0008083 [growth factor activity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0030509 [BMP signaling pathway]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048468 [cell development]
GO:0051216 [cartilage development]
GO:0060395 [SMAD protein signal transduction]
GO:0070700 [BMP receptor binding]
Show all
 402 aa
44.8 kDa 		Yes 0
BMP8B-201
ENSP00000380518
ENST00000397360
P34820 [Direct mapping]
Bone morphogenetic protein 8B
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
GO:0008083 [growth factor activity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0030509 [BMP signaling pathway]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048468 [cell development]
GO:0051216 [cartilage development]
GO:0060395 [SMAD protein signal transduction]
GO:0070700 [BMP receptor binding]
Show all
 349 aa
39.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.