We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Few hepatocellular carcinomas, renal cell carcinomas along with subset of tumor cells in few cases of duct carcinomas of breast, lymphomas and endometrial cancers displayed moderate to strong cytoplasmic immunoreactivity. Other cancer tissues were generally negative.
Weak to moderate cytoplasmic staining was observed in rare cases of a few cancer tissues. Subsets of immune cells showed weak to moderate cytoplasmic staining.
This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]