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PADI2

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GENERAL INFORMATION

Gene name

 PADI2

Gene description

 Peptidyl arginine deiminase, type II

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (SK-BR-3, RPTEC TERT1, T-47d, A549)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SK-BR-3, RPTEC TERT1, T-47d, A549)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 PADI2 (HGNC Symbol)

Synonyms

 KIAA0994, PDI2

Description

 Peptidyl arginine deiminase, type II (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.13

Chromosome location (bp)

 17066761 - 17119435

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117115 (version 83.38)

Entrez gene

 11240

UniProt

 Q9Y2J8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2J8

Antibodypedia

 PADI2 antibodies

PROTEIN BROWSER
PADI2-001
PADI2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PADI2-001
ENSP00000364635
ENST00000375486
Q9Y2J8 [Direct mapping]
Protein-arginine deiminase type-2
A0A024RA98 [Target identity:100%; Query identity:100%]
Peptidyl arginine deiminase, type II, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004668 [protein-arginine deiminase activity]
GO:0005509 [calcium ion binding]
GO:0005737 [cytoplasm]
GO:0010848 [regulation of chromatin disassembly]
GO:0018101 [protein citrullination]
GO:0021762 [substantia nigra development]
GO:0030331 [estrogen receptor binding]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0035327 [transcriptionally active chromatin]
GO:0036413 [histone H3-R26 citrullination]
GO:0048096 [chromatin-mediated maintenance of transcription]
GO:0070062 [extracellular exosome]
GO:0070100 [negative regulation of chemokine-mediated signaling pathway]
GO:1901624 [negative regulation of lymphocyte chemotaxis]
Show all
 665 aa
75.6 kDa 		No 0
PADI2-004
ENSP00000364630
ENST00000375481
Q9Y2J8 [Direct mapping]
Protein-arginine deiminase type-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004668 [protein-arginine deiminase activity]
GO:0005509 [calcium ion binding]
GO:0005737 [cytoplasm]
GO:0010848 [regulation of chromatin disassembly]
GO:0018101 [protein citrullination]
GO:0021762 [substantia nigra development]
GO:0030331 [estrogen receptor binding]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0035327 [transcriptionally active chromatin]
GO:0036413 [histone H3-R26 citrullination]
GO:0048096 [chromatin-mediated maintenance of transcription]
GO:0070062 [extracellular exosome]
GO:0070100 [negative regulation of chemokine-mediated signaling pathway]
GO:1901624 [negative regulation of lymphocyte chemotaxis]
Show all
 437 aa
49.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.