Cell atlas - RGS4 - The Human Protein Atlas

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RGS4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	RGS4
Gene description	Regulator of G-protein signaling 4
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Cell line enhanced (TIME, SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA030802
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (TIME, SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA030802	HUVEC TERT2	Endoplasmic reticulum	Intensity

GENE INFORMATION
Gene name	RGS4 (HGNC Symbol)
Synonyms	SCZD9
Description	Regulator of G-protein signaling 4 (HGNC Symbol)
Entrez gene summary	Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	163068775 - 163076802
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117152 (version 83.38)
Entrez gene	5999
UniProt	P49798 (UniProt - Evidence at protein level)
neXtProt	NX_P49798
Antibodypedia	RGS4 antibodies

PROTEIN BROWSER

RGS4-001	RGS4-002	RGS4-003	RGS4-005	RGS4-007	RGS4-009	RGS4-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RGS4-001 ENSP00000356885 ENST00000367909	P49798 [Direct mapping] Regulator of G-protein signaling 4 A0A024R909 [Target identity:100%; Query identity:100%] Regulator of G-protein signalling 4, isoform CRA_a Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0005096 [GTPase activator activity] GO:0005516 [calmodulin binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] Show all	205 aa 23.3 kDa	No	0
RGS4-002 ENSP00000356882 ENST00000367906	P49798 [Direct mapping] Regulator of G-protein signaling 4 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0005096 [GTPase activator activity] GO:0005516 [calmodulin binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] Show all	187 aa 21.5 kDa	No	0
RGS4-003 ENSP00000356884 ENST00000367908	P49798 [Direct mapping] Regulator of G-protein signaling 4 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0005096 [GTPase activator activity] GO:0005516 [calmodulin binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] Show all	93 aa 10.6 kDa	No	0
RGS4-005 ENSP00000397181 ENST00000421743	P49798 [Direct mapping] Regulator of G-protein signaling 4 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0001965 [G-protein alpha-subunit binding] GO:0005096 [GTPase activator activity] GO:0005516 [calmodulin binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0016020 [membrane] GO:0043234 [protein complex] GO:0043547 [positive regulation of GTPase activity] GO:0045744 [negative regulation of G-protein coupled receptor protein signaling pathway] Show all	302 aa 33.9 kDa	No	0
RGS4-007 ENSP00000433261 ENST00000527809	P49798 [Direct mapping] Regulator of G-protein signaling 4 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0005096 [GTPase activator activity] GO:0005516 [calmodulin binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] Show all	187 aa 21.5 kDa	No	0
RGS4-009 ENSP00000432194 ENST00000528938	E9PS05 [Direct mapping] Regulator of G-protein-signaling 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] Show all	143 aa 16.6 kDa	No	0
RGS4-010 ENSP00000436106 ENST00000531057	E9PR32 [Direct mapping] Regulator of G-protein-signaling 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] Show all	113 aa 12.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.