Cell atlas - KLHL12 - The Human Protein Atlas

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KLHL12

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubule organizing center
	Vesicles

Human cell
	Centrosome
	Vesicles

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GENERAL INFORMATION
Gene name	KLHL12
Gene description	Kelch-like family member 12
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the microtubule organizing center & vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported), Microtubule organizing center (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA071324
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the microtubule organizing center & vesicles.

Main location

Vesicles (supported), Microtubule organizing center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA071324	RH-30	Microtubule organizing center
	HPA071324	SiHa	Vesicles
	HPA071324	SiHa	Microtubule organizing center
	HPA071324	U-2 OS	Vesicles
	HPA071324	U-2 OS	Microtubule organizing center

GENE INFORMATION
Gene name	KLHL12 (HGNC Symbol)
Synonyms	C3IP1
Description	Kelch-like family member 12 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	202891100 - 202928636
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117153 (version 83.38)
Entrez gene	59349
UniProt	Q53G59 (UniProt - Evidence at protein level)
neXtProt	NX_Q53G59
Antibodypedia	KLHL12 antibodies

PROTEIN BROWSER

KLHL12-001	KLHL12-002	KLHL12-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLHL12-001 ENSP00000356230 ENST00000367261	Q53G59 [Direct mapping] Kelch-like protein 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006513 [protein monoubiquitination] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0016055 [Wnt signaling pathway] GO:0030134 [ER to Golgi transport vesicle] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0048208 [COPII vesicle coating] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	568 aa 63.3 kDa	No	0
KLHL12-002 ENSP00000356228 ENST00000367259	Q9H7R2 [Direct mapping] Kelch-like protein 12; cDNA FLJ14350 fis, clone THYRO1001721, weakly similar to RING CANAL PROTEIN Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	204 aa 22.5 kDa	No	0
KLHL12-003 ENSP00000356227 ENST00000367258	J3QSX3 [Direct mapping] Kelch-like protein 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	315 aa 36 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.