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Most cases of skin, testicular, ovarian and breast cancers, a few cases of gliomas, melanomas, lymphomas, colorectal, urothelial and cervical cancers showed distinct nuclear immunoreactivity. A majority of the remaining cancers were weakly stained or negative.
Most cancers were weakly stained or negative. Colorectal cancers and several cases of gastric, testicular and breast cancers were moderately stained.
GENE INFORMATION
Gene name
ID3 (HGNC Symbol)
Synonyms
bHLHb25, HEIR-1
Description
Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]
Q02535 [Direct mapping] DNA-binding protein inhibitor ID-3
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Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001656 [metanephros development] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006275 [regulation of DNA replication] GO:0006351 [transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0007417 [central nervous system development] GO:0007507 [heart development] GO:0007517 [muscle organ development] GO:0007623 [circadian rhythm] GO:0008134 [transcription factor binding] GO:0009611 [response to wounding] GO:0015630 [microtubule cytoskeleton] GO:0019904 [protein domain specific binding] GO:0030182 [neuron differentiation] GO:0030855 [epithelial cell differentiation] GO:0030903 [notochord development] GO:0042476 [odontogenesis] GO:0043065 [positive regulation of apoptotic process] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045662 [negative regulation of myoblast differentiation] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity] GO:0051726 [regulation of cell cycle]
