Cell atlas - CR2 - The Human Protein Atlas

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CR2

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CR2
Gene description	Complement component (3d/Epstein Barr virus) receptor 2
Protein class	CD markers Disease related genes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (Daudi, MOLT-4)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Daudi, MOLT-4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CR2 (HGNC Symbol)
Synonyms	CD21
Description	Complement component (3d/Epstein Barr virus) receptor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Chromosome	1
Cytoband	q32.2
Chromosome location (bp)	207454230 - 207489895
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117322 (version 83.38)
Entrez gene	1380
UniProt	P20023 (UniProt - Evidence at protein level)
neXtProt	NX_P20023
Antibodypedia	CR2 antibodies

PROTEIN BROWSER

CR2-001	CR2-002	CR2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CR2-001 ENSP00000356025 ENST00000367058	P20023 [Direct mapping] Complement receptor type 2 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0001848 [complement binding] GO:0003677 [DNA binding] GO:0004875 [complement receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0006958 [complement activation, classical pathway] GO:0016021 [integral component of membrane] GO:0030183 [B cell differentiation] GO:0042100 [B cell proliferation] GO:0042803 [protein homodimerization activity] GO:0043235 [receptor complex] GO:0045087 [innate immune response] GO:0046718 [viral entry into host cell] GO:0070062 [extracellular exosome] Show all	1033 aa 112.9 kDa	Yes	1
CR2-002 ENSP00000356026 ENST00000367059	Q5SR47 [Direct mapping] Complement receptor type 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	971 aa 106.4 kDa	Yes	1
CR2-003 ENSP00000356024 ENST00000367057	P20023 [Direct mapping] Complement receptor type 2 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0001848 [complement binding] GO:0002430 [complement receptor mediated signaling pathway] GO:0003677 [DNA binding] GO:0004872 [receptor activity] GO:0004875 [complement receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0006958 [complement activation, classical pathway] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0030183 [B cell differentiation] GO:0042100 [B cell proliferation] GO:0042113 [B cell activation] GO:0042803 [protein homodimerization activity] GO:0043235 [receptor complex] GO:0045087 [innate immune response] GO:0046718 [viral entry into host cell] GO:0070062 [extracellular exosome] Show all	1092 aa 119.2 kDa	Yes	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.