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CD46

CANCER ATLAS

Gene description

 CD46 molecule, complement regulatory protein

Protein class

 Cancer-related genes, CD markers, Disease related genes, Plasma proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA016903
CAB010401

GENE INFORMATION

Gene name

 CD46 (HGNC Symbol)

Synonyms

 MCP, MGC26544, MIC10, TLX, TRA2.10

Description

 CD46 molecule, complement regulatory protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

Chromosome

 1

Cytoband

 q32.2

Chromosome location (bp)

 207752057 - 207795513

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117335 (version 83.38)

Entrez gene

 4179

UniProt

 P15529 (UniProt - Evidence at protein level)

neXtProt

 NX_P15529

Antibodypedia

 CD46 antibodies

PROTEIN BROWSER
«
CD46-001
CD46-002
CD46-003
CD46-004
CD46-005
CD46-006
CD46-007
CD46-008
CD46-011
CD46-012
CD46-013
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD46-001
ENSP00000350893
ENST00000358170
P15529 [Direct mapping]
Membrane cofactor protein
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002079 [inner acrosomal membrane]
GO:0002250 [adaptive immune response]
GO:0002456 [T cell mediated immunity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006958 [complement activation, classical pathway]
GO:0007338 [single fertilization]
GO:0008593 [regulation of Notch signaling pathway]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0030449 [regulation of complement activation]
GO:0032613 [interleukin-10 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0035581 [sequestering of extracellular ligand from receptor]
GO:0042102 [positive regulation of T cell proliferation]
GO:0043382 [positive regulation of memory T cell differentiation]
GO:0045087 [innate immune response]
GO:0045296 [cadherin binding]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0046718 [viral entry into host cell]
GO:0070062 [extracellular exosome]
GO:0071636 [positive regulation of transforming growth factor beta production]
Show all
 392 aa
43.7 kDa 		Yes 1
CD46-002
ENSP00000346912
ENST00000354848
P15529 [Direct mapping]
Membrane cofactor protein
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002079 [inner acrosomal membrane]
GO:0002250 [adaptive immune response]
GO:0002456 [T cell mediated immunity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006958 [complement activation, classical pathway]
GO:0007338 [single fertilization]
GO:0008593 [regulation of Notch signaling pathway]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0030449 [regulation of complement activation]
GO:0032613 [interleukin-10 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0035581 [sequestering of extracellular ligand from receptor]
GO:0042102 [positive regulation of T cell proliferation]
GO:0043382 [positive regulation of memory T cell differentiation]
GO:0045087 [innate immune response]
GO:0045296 [cadherin binding]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0046718 [viral entry into host cell]
GO:0070062 [extracellular exosome]
GO:0071636 [positive regulation of transforming growth factor beta production]
Show all
 384 aa
42.7 kDa 		Yes 1
CD46-003
ENSP00000314664
ENST00000322918
P15529 [Direct mapping]
Membrane cofactor protein
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002079 [inner acrosomal membrane]
GO:0002250 [adaptive immune response]
GO:0002456 [T cell mediated immunity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006958 [complement activation, classical pathway]
GO:0007338 [single fertilization]
GO:0008593 [regulation of Notch signaling pathway]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0030449 [regulation of complement activation]
GO:0032613 [interleukin-10 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0035581 [sequestering of extracellular ligand from receptor]
GO:0042102 [positive regulation of T cell proliferation]
GO:0043382 [positive regulation of memory T cell differentiation]
GO:0045087 [innate immune response]
GO:0045296 [cadherin binding]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0046718 [viral entry into host cell]
GO:0070062 [extracellular exosome]
GO:0071636 [positive regulation of transforming growth factor beta production]
Show all
 349 aa
39.3 kDa 		Yes 1
CD46-004
ENSP00000356009
ENST00000367042
P15529 [Direct mapping]
Membrane cofactor protein
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002079 [inner acrosomal membrane]
GO:0002250 [adaptive immune response]
GO:0002456 [T cell mediated immunity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006958 [complement activation, classical pathway]
GO:0007338 [single fertilization]
GO:0008593 [regulation of Notch signaling pathway]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0030449 [regulation of complement activation]
GO:0032613 [interleukin-10 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0035581 [sequestering of extracellular ligand from receptor]
GO:0042102 [positive regulation of T cell proliferation]
GO:0043382 [positive regulation of memory T cell differentiation]
GO:0045087 [innate immune response]
GO:0045296 [cadherin binding]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0046718 [viral entry into host cell]
GO:0070062 [extracellular exosome]
GO:0071636 [positive regulation of transforming growth factor beta production]
Show all
 377 aa
42.2 kDa 		Yes 1
CD46-005
ENSP00000356008
ENST00000367041
P15529 [Direct mapping]
Membrane cofactor protein
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002079 [inner acrosomal membrane]
GO:0002250 [adaptive immune response]
GO:0002456 [T cell mediated immunity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006958 [complement activation, classical pathway]
GO:0007338 [single fertilization]
GO:0008593 [regulation of Notch signaling pathway]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0030449 [regulation of complement activation]
GO:0032613 [interleukin-10 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0035581 [sequestering of extracellular ligand from receptor]
GO:0042102 [positive regulation of T cell proliferation]
GO:0043382 [positive regulation of memory T cell differentiation]
GO:0045087 [innate immune response]
GO:0045296 [cadherin binding]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0046718 [viral entry into host cell]
GO:0070062 [extracellular exosome]
GO:0071636 [positive regulation of transforming growth factor beta production]
Show all
 362 aa
40.9 kDa 		Yes 1
CD46-006
ENSP00000350346
ENST00000357714
P15529 [Direct mapping]
Membrane cofactor protein
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002079 [inner acrosomal membrane]
GO:0002250 [adaptive immune response]
GO:0002456 [T cell mediated immunity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006958 [complement activation, classical pathway]
GO:0007338 [single fertilization]
GO:0008593 [regulation of Notch signaling pathway]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0030449 [regulation of complement activation]
GO:0032613 [interleukin-10 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0035581 [sequestering of extracellular ligand from receptor]
GO:0042102 [positive regulation of T cell proliferation]
GO:0043382 [positive regulation of memory T cell differentiation]
GO:0045087 [innate immune response]
GO:0045296 [cadherin binding]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0046718 [viral entry into host cell]
GO:0070062 [extracellular exosome]
GO:0071636 [positive regulation of transforming growth factor beta production]
Show all
 369 aa
41.4 kDa 		Yes 1
CD46-007
ENSP00000313875
ENST00000322875
P15529 [Direct mapping]
Membrane cofactor protein
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001669 [acrosomal vesicle]
GO:0001848 [complement binding]
GO:0002079 [inner acrosomal membrane]
GO:0002250 [adaptive immune response]
GO:0002456 [T cell mediated immunity]
GO:0004175 [endopeptidase activity]
GO:0004857 [enzyme inhibitor activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006508 [proteolysis]
GO:0006958 [complement activation, classical pathway]
GO:0007338 [single fertilization]
GO:0008593 [regulation of Notch signaling pathway]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0016323 [basolateral plasma membrane]
GO:0030449 [regulation of complement activation]
GO:0032613 [interleukin-10 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0035581 [sequestering of extracellular ligand from receptor]
GO:0042102 [positive regulation of T cell proliferation]
GO:0043086 [negative regulation of catalytic activity]
GO:0043382 [positive regulation of memory T cell differentiation]
GO:0045087 [innate immune response]
GO:0045296 [cadherin binding]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0045916 [negative regulation of complement activation]
GO:0046718 [viral entry into host cell]
GO:0070062 [extracellular exosome]
GO:0071636 [positive regulation of transforming growth factor beta production]
Show all
 399 aa
44.2 kDa 		Yes 1
CD46-008
ENSP00000356014
ENST00000367047
P15529 [Direct mapping]
Membrane cofactor protein
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002079 [inner acrosomal membrane]
GO:0002250 [adaptive immune response]
GO:0002456 [T cell mediated immunity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006958 [complement activation, classical pathway]
GO:0007338 [single fertilization]
GO:0008593 [regulation of Notch signaling pathway]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0030449 [regulation of complement activation]
GO:0032613 [interleukin-10 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0035581 [sequestering of extracellular ligand from receptor]
GO:0042102 [positive regulation of T cell proliferation]
GO:0043382 [positive regulation of memory T cell differentiation]
GO:0045087 [innate immune response]
GO:0045296 [cadherin binding]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0046718 [viral entry into host cell]
GO:0070062 [extracellular exosome]
GO:0071636 [positive regulation of transforming growth factor beta production]
Show all
 336 aa
36.8 kDa 		Yes 1
CD46-011
ENSP00000473449
ENST00000462968
R4GN18 [Direct mapping]
Membrane cofactor protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 78 aa
8.4 kDa 		No 1
CD46-012
ENSP00000353342
ENST00000360212
P15529 [Direct mapping]
Membrane cofactor protein
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002079 [inner acrosomal membrane]
GO:0002250 [adaptive immune response]
GO:0002456 [T cell mediated immunity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006958 [complement activation, classical pathway]
GO:0007338 [single fertilization]
GO:0008593 [regulation of Notch signaling pathway]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0030449 [regulation of complement activation]
GO:0032613 [interleukin-10 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0035581 [sequestering of extracellular ligand from receptor]
GO:0042102 [positive regulation of T cell proliferation]
GO:0043382 [positive regulation of memory T cell differentiation]
GO:0045087 [innate immune response]
GO:0045296 [cadherin binding]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0046718 [viral entry into host cell]
GO:0070062 [extracellular exosome]
GO:0071636 [positive regulation of transforming growth factor beta production]
Show all
 355 aa
39.8 kDa 		Yes 1
CD46-013
ENSP00000418471
ENST00000480003
P15529 [Direct mapping]
Membrane cofactor protein
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002079 [inner acrosomal membrane]
GO:0002250 [adaptive immune response]
GO:0002456 [T cell mediated immunity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006958 [complement activation, classical pathway]
GO:0007338 [single fertilization]
GO:0008593 [regulation of Notch signaling pathway]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0030449 [regulation of complement activation]
GO:0032613 [interleukin-10 production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0035581 [sequestering of extracellular ligand from receptor]
GO:0042102 [positive regulation of T cell proliferation]
GO:0043382 [positive regulation of memory T cell differentiation]
GO:0045087 [innate immune response]
GO:0045296 [cadherin binding]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0046718 [viral entry into host cell]
GO:0070062 [extracellular exosome]
GO:0071636 [positive regulation of transforming growth factor beta production]
Show all
 370 aa
41.2 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.