Cell atlas - ARTN - The Human Protein Atlas

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ARTN

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	ARTN
Gene description	Artemin
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Cell line enhanced (HaCaT, A-431)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA060012
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT, A-431) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA060012	A-431	Mitochondria
	HPA060012	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	ARTN (HGNC Symbol)
Synonyms	ENOVIN, EVN, NBN
Description	Artemin (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Chromosome	1
Cytoband	p34.1
Chromosome location (bp)	43933320 - 43937241
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117407 (version 83.38)
Entrez gene	9048
UniProt	Q5T4W7 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T4W7
Antibodypedia	ARTN antibodies

PROTEIN BROWSER

ARTN-001	ARTN-002	ARTN-003	ARTN-004	ARTN-005	ARTN-006	ARTN-007	ARTN-008	ARTN-009	ARTN-010	ARTN-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARTN-001 ENSP00000361434 ENST00000372359	Q5T4W7 [Direct mapping] Artemin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005102 [receptor binding] GO:0007165 [signal transduction] GO:0007405 [neuroblast proliferation] GO:0007411 [axon guidance] GO:0008083 [growth factor activity] Show all	220 aa 22.9 kDa	Yes	0
ARTN-002 ENSP00000361429 ENST00000372354	Q5T4W7 [Direct mapping] Artemin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005102 [receptor binding] GO:0007165 [signal transduction] GO:0007405 [neuroblast proliferation] GO:0007411 [axon guidance] GO:0008083 [growth factor activity] Show all	220 aa 22.9 kDa	Yes	0
ARTN-003 ENSP00000436727 ENST00000498139	Q5T4W7 [Direct mapping] Artemin Show all	Phobius predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005102 [receptor binding] GO:0007165 [signal transduction] GO:0007405 [neuroblast proliferation] GO:0007411 [axon guidance] GO:0008083 [growth factor activity] Show all	228 aa 23.6 kDa	Yes	0
ARTN-004 ENSP00000434784 ENST00000477048	E9PIK2 [Direct mapping] Artemin Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		66 aa 6.7 kDa	Yes	0
ARTN-005 ENSP00000435804 ENST00000471394	E9PIK2 [Direct mapping] Artemin Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		66 aa 6.7 kDa	Yes	0
ARTN-006 ENSP00000435140 ENST00000472435	E9PLG3 [Direct mapping] Artemin Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		76 aa 7.6 kDa	Yes	0
ARTN-007 ENSP00000436149 ENST00000491846	E9PN22 [Direct mapping] Artemin Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		89 aa 9.1 kDa	Yes	0
ARTN-008 ENSP00000434071 ENST00000479128	E9PLG3 [Direct mapping] Artemin Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		76 aa 7.6 kDa	Yes	0
ARTN-009 ENSP00000434856 ENST00000474592	E9PN22 [Direct mapping] Artemin Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		89 aa 9.1 kDa	Yes	0
ARTN-010 ENSP00000391998 ENST00000438616	Q5T4W7 [Direct mapping] Artemin Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0005102 [receptor binding] GO:0007165 [signal transduction] GO:0007405 [neuroblast proliferation] GO:0007411 [axon guidance] GO:0008083 [growth factor activity] Show all	237 aa 24.5 kDa	No	0
ARTN-201 ENSP00000387435 ENST00000414809	Q5T4W7 [Direct mapping] Artemin Show all	Phobius predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0007405 [neuroblast proliferation] GO:0007411 [axon guidance] GO:0007422 [peripheral nervous system development] GO:0008083 [growth factor activity] GO:0050930 [induction of positive chemotaxis] GO:0061146 [Peyer's patch morphogenesis] GO:0097021 [lymphocyte migration into lymphoid organs] Show all	228 aa 23.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.