Tissue expression of ATP6V0B - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ATP6V0B
Gene description	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ATP6V0B (HGNC Symbol)
Synonyms	ATP6F, HATPL, VMA16
Description	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (HGNC Symbol)
Entrez gene summary	This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Chromosome	1
Cytoband	p34.1
Chromosome location (bp)	43974487 - 43978295
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000117410 (version 83.38)
Entrez gene	533
UniProt	Q99437 (UniProt - Evidence at transcript level)
neXtProt	NX_Q99437
Antibodypedia	ATP6V0B antibodies

PROTEIN BROWSER

ATP6V0B-001	ATP6V0B-004	ATP6V0B-006	ATP6V0B-011	ATP6V0B-012	ATP6V0B-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP6V0B-001 ENSP00000431605 ENST00000472174	Q99437 [Direct mapping] V-type proton ATPase 21 kDa proteolipid subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain] GO:0005215 [transporter activity] GO:0006879 [cellular iron ion homeostasis] GO:0007035 [vacuolar acidification] GO:0008286 [insulin receptor signaling pathway] GO:0010008 [endosome membrane] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0030670 [phagocytic vesicle membrane] GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0055085 [transmembrane transport] GO:0090382 [phagosome maturation] Show all	205 aa 21.4 kDa	No	5
ATP6V0B-004 ENSP00000236067 ENST00000236067	Q99437 [Direct mapping] V-type proton ATPase 21 kDa proteolipid subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain] GO:0005215 [transporter activity] GO:0006879 [cellular iron ion homeostasis] GO:0007035 [vacuolar acidification] GO:0008286 [insulin receptor signaling pathway] GO:0010008 [endosome membrane] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0030670 [phagocytic vesicle membrane] GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0055085 [transmembrane transport] GO:0090382 [phagosome maturation] Show all	158 aa 16.2 kDa	No	3
ATP6V0B-006 ENSP00000432754 ENST00000471859	E9PNU0 [Direct mapping] V-type proton ATPase 21 kDa proteolipid subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain] GO:0033179 [proton-transporting V-type ATPase, V0 domain] Show all	252 aa 26.1 kDa	Yes	4
ATP6V0B-011 ENSP00000434094 ENST00000498664	Q99437 [Direct mapping] V-type proton ATPase 21 kDa proteolipid subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain] GO:0005215 [transporter activity] GO:0006879 [cellular iron ion homeostasis] GO:0007035 [vacuolar acidification] GO:0008286 [insulin receptor signaling pathway] GO:0010008 [endosome membrane] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0030670 [phagocytic vesicle membrane] GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0055085 [transmembrane transport] GO:0090382 [phagosome maturation] Show all	158 aa 16.2 kDa	No	3
ATP6V0B-012 ENSP00000434729 ENST00000532642	E9PNL3 [Direct mapping] V-type proton ATPase 21 kDa proteolipid subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005768 [endosome] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain] GO:0033179 [proton-transporting V-type ATPase, V0 domain] Show all	261 aa 27.7 kDa	No	5
ATP6V0B-013 ENSP00000432994 ENST00000472505	E9PMR1 [Direct mapping] V-type proton ATPase 21 kDa proteolipid subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain] GO:0033179 [proton-transporting V-type ATPase, V0 domain] Show all	86 aa 9 kDa	No	2