Expression of B4GALT2 in cancer - Summary

CANCER ATLAS

Gene description

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA047739

GENE INFORMATION
Gene name	B4GALT2 (HGNC Symbol)
Synonyms	beta4Gal-T2
Description	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 (HGNC Symbol)
Entrez gene summary	This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Chromosome	1
Cytoband	p34.1
Chromosome location (bp)	43978943 - 43991170
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117411 (version 83.38)
Entrez gene	8704
UniProt	O60909 (UniProt - Evidence at protein level)
neXtProt	NX_O60909
Antibodypedia	B4GALT2 antibodies

PROTEIN BROWSER

B4GALT2-001	B4GALT2-002	B4GALT2-201	B4GALT2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
B4GALT2-001 ENSP00000349293 ENST00000356836	O60909 [Direct mapping] Beta-1,4-galactosyltransferase 2 Lactose synthase A protein N-acetyllactosamine synthase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003831 [beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity] GO:0003945 [N-acetyllactosamine synthase activity] GO:0004461 [lactose synthase activity] GO:0005975 [carbohydrate metabolic process] GO:0008378 [galactosyltransferase activity] GO:0016021 [integral component of membrane] GO:0018146 [keratan sulfate biosynthetic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030203 [glycosaminoglycan metabolic process] GO:0032580 [Golgi cisterna membrane] GO:0042339 [keratan sulfate metabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	372 aa 42 kDa	No	1
B4GALT2-002 ENSP00000407468 ENST00000434555	O60909 [Direct mapping] Beta-1,4-galactosyltransferase 2 Lactose synthase A protein N-acetyllactosamine synthase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase Show all	Enzymes ENZYME proteins Transferases Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003831 [beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity] GO:0003945 [N-acetyllactosamine synthase activity] GO:0004461 [lactose synthase activity] GO:0005975 [carbohydrate metabolic process] GO:0008378 [galactosyltransferase activity] GO:0016021 [integral component of membrane] GO:0018146 [keratan sulfate biosynthetic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030203 [glycosaminoglycan metabolic process] GO:0032580 [Golgi cisterna membrane] GO:0042339 [keratan sulfate metabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	306 aa 34.9 kDa	No	0
B4GALT2-201 ENSP00000310696 ENST00000309519	O60909 [Direct mapping] Beta-1,4-galactosyltransferase 2 Lactose synthase A protein N-acetyllactosamine synthase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003831 [beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity] GO:0003945 [N-acetyllactosamine synthase activity] GO:0004461 [lactose synthase activity] GO:0005975 [carbohydrate metabolic process] GO:0008378 [galactosyltransferase activity] GO:0016021 [integral component of membrane] GO:0018146 [keratan sulfate biosynthetic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030203 [glycosaminoglycan metabolic process] GO:0032580 [Golgi cisterna membrane] GO:0042339 [keratan sulfate metabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	401 aa 44.8 kDa	No	1
B4GALT2-202 ENSP00000361399 ENST00000372324	O60909 [Direct mapping] Beta-1,4-galactosyltransferase 2 Lactose synthase A protein N-acetyllactosamine synthase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003831 [beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity] GO:0003945 [N-acetyllactosamine synthase activity] GO:0004461 [lactose synthase activity] GO:0005975 [carbohydrate metabolic process] GO:0008378 [galactosyltransferase activity] GO:0016021 [integral component of membrane] GO:0018146 [keratan sulfate biosynthetic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030203 [glycosaminoglycan metabolic process] GO:0032580 [Golgi cisterna membrane] GO:0042339 [keratan sulfate metabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	372 aa 42 kDa	No	1