Fields »
ABOUT
HELP
BLOG
TSPAN1

GENERAL INFORMATION

Gene name

 TSPAN1

Gene description

 Tetraspanin 1

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (rectum, colon)
GTEx:Tissue enhanced (kidney, colon)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Membrane and cytoplasmic expression, most abundant in rectum and colon.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA011909
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (rectum, colon)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney, colon)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 TSPAN1 (HGNC Symbol)

Synonyms

 NET-1, TSPAN-1

Description

 Tetraspanin 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p34.1

Chromosome location (bp)

 46175073 - 46185958

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117472 (version 83.38)

Entrez gene

 10103

UniProt

 O60635 (UniProt - Evidence at protein level)

neXtProt

 NX_O60635

Antibodypedia

 TSPAN1 antibodies

PROTEIN BROWSER
TSPAN1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TSPAN1-001
ENSP00000361072
ENST00000372003
O60635 [Direct mapping]
Tetraspanin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0031982 [vesicle]
GO:0045807 [positive regulation of endocytosis]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050821 [protein stabilization]
GO:0070062 [extracellular exosome]
Show all
 241 aa
26.3 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.