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A majority of malignant cells showed weak cytoplasmic immunoreactivity. Strong cytoplasmic and membranous staining was observed in several skin, pancreatic, prostate and cervical cancers.
GENE INFORMATION
Gene name
F3 (HGNC Symbol)
Synonyms
CD142
Description
Coagulation factor III (thromboplastin, tissue factor) (HGNC Symbol)
Entrez gene summary
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
CD markers MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002020 [protease binding] GO:0002541 [activation of plasma proteins involved in acute inflammatory response] GO:0002543 [activation of blood coagulation via clotting cascade] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007596 [blood coagulation] GO:0007598 [blood coagulation, extrinsic pathway] GO:0009986 [cell surface] GO:0010641 [positive regulation of platelet-derived growth factor receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030335 [positive regulation of cell migration] GO:0031012 [extracellular matrix] GO:0031233 [intrinsic component of external side of plasma membrane] GO:0045766 [positive regulation of angiogenesis] GO:0050927 [positive regulation of positive chemotaxis] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070062 [extracellular exosome]