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Rare cases of liver, colorectal, ovarian, endometrial, stomach, testis and head and neck cancers exhibited moderate cytoplasmic positivity. Remaining cancers were weakly stained or negative.
GENE INFORMATION
Gene name
FASLG (HGNC Symbol)
Synonyms
APT1LG1, CD178, FasL, TNFSF6
Description
Fas ligand (TNF superfamily, member 6) (HGNC Symbol)
Entrez gene summary
This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]