Expression of DARS2 in cancer - Summary

CANCER ATLAS

Gene description

Aspartyl-tRNA synthetase 2, mitochondrial

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA026506	HPA026528

GENE INFORMATION
Gene name	DARS2 (HGNC Symbol)
Synonyms	FLJ10514
Description	Aspartyl-tRNA synthetase 2, mitochondrial (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL). [provided by RefSeq, Nov 2009]
Chromosome	1
Cytoband	q25.1
Chromosome location (bp)	173824503 - 173858546
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117593 (version 83.38)
Entrez gene	55157
UniProt	Q6PI48 (UniProt - Evidence at protein level)
neXtProt	NX_Q6PI48
Antibodypedia	DARS2 antibodies

PROTEIN BROWSER

DARS2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DARS2-001 ENSP00000355086 ENST00000361951	Q6PI48 [Direct mapping] Aspartate--tRNA ligase, mitochondrial A0A024R8Z9 [Target identity:100%; Query identity:100%] Aspartyl-tRNA synthetase 2 (Mitochondrial), isoform CRA_b Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004815 [aspartate-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006418 [tRNA aminoacylation for protein translation] GO:0010467 [gene expression] GO:0016874 [ligase activity] GO:0042803 [protein homodimerization activity] GO:0043039 [tRNA aminoacylation] GO:0050560 [aspartate-tRNA(Asn) ligase activity] GO:0070145 [mitochondrial asparaginyl-tRNA aminoacylation] Show all	645 aa 73.6 kDa	No	0