Expression of HSD11B1 in cancer - Summary

CANCER ATLAS

Gene description

Hydroxysteroid (11-beta) dehydrogenase 1

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA047729

GENE INFORMATION
Gene name	HSD11B1 (HGNC Symbol)
Synonyms	HSD11, HSD11B, SDR26C1
Description	Hydroxysteroid (11-beta) dehydrogenase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]
Chromosome	1
Cytoband	q32.2
Chromosome location (bp)	209686178 - 209734950
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117594 (version 83.38)
Entrez gene	3290
UniProt	P28845 (UniProt - Evidence at protein level)
neXtProt	NX_P28845
Antibodypedia	HSD11B1 antibodies

PROTEIN BROWSER

HSD11B1-001	HSD11B1-002	HSD11B1-003	HSD11B1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HSD11B1-001 ENSP00000355994 ENST00000367027	P28845 [Direct mapping] Corticosteroid 11-beta-dehydrogenase isozyme 1 X5D2L1 [Target identity:100%; Query identity:100%] Hydroxysteroid 11-beta dehydrogenase 1 isoform A Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006704 [glucocorticoid biosynthetic process] GO:0008152 [metabolic process] GO:0008202 [steroid metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070524 [11-beta-hydroxysteroid dehydrogenase (NADP+) activity] Show all	292 aa 32.4 kDa	No	0
HSD11B1-002 ENSP00000261465 ENST00000261465	A0A0A0MQV1 [Direct mapping] Corticosteroid 11-beta-dehydrogenase isozyme 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	279 aa 30.8 kDa	No	0
HSD11B1-003 ENSP00000478430 ENST00000615289	A0A087WU76 [Direct mapping] Corticosteroid 11-beta-dehydrogenase isozyme 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	182 aa 20 kDa	No	0
HSD11B1-201 ENSP00000355995 ENST00000367028	P28845 [Direct mapping] Corticosteroid 11-beta-dehydrogenase isozyme 1 X5D2L1 [Target identity:100%; Query identity:100%] Hydroxysteroid 11-beta dehydrogenase 1 isoform A Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003845 [11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006704 [glucocorticoid biosynthetic process] GO:0008152 [metabolic process] GO:0008202 [steroid metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0030324 [lung development] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070524 [11-beta-hydroxysteroid dehydrogenase (NADP+) activity] Show all	292 aa 32.4 kDa	No	0