Tissue expression of PLPPR4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PLPPR4
Gene description	Phospholipid phosphatase related 4
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (hippocampus, caudate, cerebral cortex, pituitary gland, hypothalamus, urinary bladder)
FANTOM5:	Group enriched (hippocampus, caudate, pituitary gland, brain)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (hippocampus, caudate, cerebral cortex, pituitary gland, hypothalamus, urinary bladder)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (hippocampus, caudate, pituitary gland, brain)

GENE INFORMATION
Gene name	PLPPR4 (HGNC Symbol)
Synonyms	KIAA0455, LPPR4, PHP1, PRG-1
Description	Phospholipid phosphatase related 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Chromosome	1
Cytoband
Chromosome location (bp)	99263953 - 99309590
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117600 (version 83.38)
Entrez gene	9890
UniProt	Q7Z2D5 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z2D5
Antibodypedia	PLPPR4 antibodies

PROTEIN BROWSER

PLPPR4-001	PLPPR4-002	PLPPR4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLPPR4-001 ENSP00000359204 ENST00000370185	Q7Z2D5 [Target identity:100%; Query identity:100%] Lipid phosphate phosphatase-related protein type 4 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0007165 [signal transduction] GO:0007409 [axonogenesis] GO:0008195 [phosphatidate phosphatase activity] GO:0009897 [external side of plasma membrane] GO:0042577 [lipid phosphatase activity] GO:0046839 [phospholipid dephosphorylation] GO:0048839 [inner ear development] Show all	763 aa 83 kDa	No	6
PLPPR4-002 ENSP00000359203 ENST00000370184	W4VSQ3 [Direct mapping] Lipid phosphate phosphatase-related protein type 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005887 [integral component of plasma membrane] GO:0007409 [axonogenesis] GO:0042577 [lipid phosphatase activity] GO:0046839 [phospholipid dephosphorylation] Show all	605 aa 66.2 kDa	No	4
PLPPR4-201 ENSP00000394913 ENST00000457765	A0A0A6YYH7 [Direct mapping] Lipid phosphate phosphatase-related protein type 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0007409 [axonogenesis] GO:0042577 [lipid phosphatase activity] GO:0046839 [phospholipid dephosphorylation] Show all	705 aa 76.6 kDa	No	4