Expression of SLC35A3 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA015253

GENE INFORMATION
Gene name	SLC35A3
Synonyms
Description	Solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 (HGNC Symbol)
Entrez gene summary	This gene encodes a UDP-N-acetylglucosamine transporter found in the golgi apparatus membrane. In cattle, a missense mutation in this gene causes complex vertebral malformation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Chromosome	1
Cytoband	p21.2
Chromosome location (bp)	99969789 - 100026979
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117620 (version 83.38)
Entrez gene	23443
UniProt	Q9Y2D2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2D2
Antibodypedia	SLC35A3 antibodies

PROTEIN BROWSER

SLC35A3-001	SLC35A3-002	SLC35A3-004	SLC35A3-005	SLC35A3-008	SLC35A3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC35A3-001 ENSP00000359174 ENST00000370155	Q9Y2D2 [Direct mapping] UDP-N-acetylglucosamine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005338 [nucleotide-sugar transmembrane transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005462 [UDP-N-acetylglucosamine transmembrane transporter activity] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0006047 [UDP-N-acetylglucosamine metabolic process] GO:0008643 [carbohydrate transport] GO:0015780 [nucleotide-sugar transport] GO:0015788 [UDP-N-acetylglucosamine transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:1990569 [UDP-N-acetylglucosamine transmembrane transport] Show all	325 aa 36 kDa	No	8
SLC35A3-002 ENSP00000418527 ENST00000465289	Q9Y2D2 [Direct mapping] UDP-N-acetylglucosamine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0000139 [Golgi membrane] GO:0005338 [nucleotide-sugar transmembrane transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005462 [UDP-N-acetylglucosamine transmembrane transporter activity] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0006047 [UDP-N-acetylglucosamine metabolic process] GO:0008643 [carbohydrate transport] GO:0015780 [nucleotide-sugar transport] GO:0015788 [UDP-N-acetylglucosamine transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:1990569 [UDP-N-acetylglucosamine transmembrane transport] Show all	220 aa 24.5 kDa	No	4
SLC35A3-004 ENSP00000414947 ENST00000427993	Q9Y2D2 [Direct mapping] UDP-N-acetylglucosamine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0000139 [Golgi membrane] GO:0005338 [nucleotide-sugar transmembrane transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005462 [UDP-N-acetylglucosamine transmembrane transporter activity] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0006047 [UDP-N-acetylglucosamine metabolic process] GO:0008643 [carbohydrate transport] GO:0015780 [nucleotide-sugar transport] GO:0015788 [UDP-N-acetylglucosamine transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:1990569 [UDP-N-acetylglucosamine transmembrane transport] Show all	325 aa 36 kDa	No	8
SLC35A3-005 ENSP00000401679 ENST00000422078	C9JW63 [Direct mapping] UDP-N-acetylglucosamine transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0005338 [nucleotide-sugar transmembrane transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0008643 [carbohydrate transport] GO:0015780 [nucleotide-sugar transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:1901679 [nucleotide transmembrane transport] Show all	224 aa 25 kDa	No	5
SLC35A3-008 ENSP00000436938 ENST00000532693	E9PPQ9 [Direct mapping] UDP-N-acetylglucosamine transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0005351 [sugar:proton symporter activity] GO:0008643 [carbohydrate transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] Show all	85 aa 9.7 kDa	No	2
SLC35A3-201 ENSP00000359172 ENST00000370153	Q9Y2D2 [Direct mapping] UDP-N-acetylglucosamine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0000139 [Golgi membrane] GO:0005338 [nucleotide-sugar transmembrane transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005462 [UDP-N-acetylglucosamine transmembrane transporter activity] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0006047 [UDP-N-acetylglucosamine metabolic process] GO:0008643 [carbohydrate transport] GO:0015780 [nucleotide-sugar transport] GO:0015788 [UDP-N-acetylglucosamine transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:1990569 [UDP-N-acetylglucosamine transmembrane transport] Show all	367 aa 40.7 kDa	No	8