Fields »
ABOUT
HELP
BLOG
NEK2

GENERAL INFORMATION

Gene name

 NEK2

Gene description

 NIMA-related kinase 2

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
CAB017530
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 NEK2 (HGNC Symbol)

Synonyms

 NEK2A, NLK1, PPP1R111, RP67

Description

 NIMA-related kinase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011]

Chromosome

 1

Cytoband

 q32.3

Chromosome location (bp)

 211658657 - 211675630

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000117650 (version 83.38)

Entrez gene

 4751

UniProt

 P51955 (UniProt - Evidence at protein level)

neXtProt

 NX_P51955

Antibodypedia

 NEK2 antibodies

PROTEIN BROWSER
NEK2-001
NEK2-002
NEK2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NEK2-001
ENSP00000355966
ENST00000366999
P51955 [Direct mapping]
Serine/threonine-protein kinase Nek2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000070 [mitotic sister chromatid segregation]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000794 [condensed nuclear chromosome]
GO:0000922 [spindle pole]
GO:0001824 [blastocyst development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006468 [protein phosphorylation]
GO:0006996 [organelle organization]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0019903 [protein phosphatase binding]
GO:0030496 [midbody]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0043234 [protein complex]
GO:0043392 [negative regulation of DNA binding]
GO:0045171 [intercellular bridge]
GO:0046602 [regulation of mitotic centrosome separation]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0051225 [spindle assembly]
GO:0051299 [centrosome separation]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:0090307 [mitotic spindle assembly]
GO:1903126 [negative regulation of centriole-centriole cohesion]
Show all
 445 aa
51.8 kDa 		No 0
NEK2-002
ENSP00000355965
ENST00000366998
P51955 [Direct mapping]
Serine/threonine-protein kinase Nek2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006468 [protein phosphorylation]
GO:0006996 [organelle organization]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007088 [regulation of mitotic nuclear division]
GO:0019903 [protein phosphatase binding]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0043234 [protein complex]
GO:0045171 [intercellular bridge]
GO:0046602 [regulation of mitotic centrosome separation]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0051225 [spindle assembly]
GO:0051299 [centrosome separation]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:1903126 [negative regulation of centriole-centriole cohesion]
Show all
 384 aa
44.9 kDa 		No 0
NEK2-201
ENSP00000440237
ENST00000540251
F6U4U2 [Direct mapping]
Serine/threonine-protein kinase Nek2
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 388 aa
45.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.