Tissue expression of DHDDS - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

DHDDS

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	DHDDS
Gene description	Dehydrodolichyl diphosphate synthase subunit
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	16
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most cell types.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA026721 , HPA026727
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DHDDS (HGNC Symbol)
Synonyms	DS, FLJ13102, HDS, RP59
Description	Dehydrodolichyl diphosphate synthase subunit (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Chromosome	1
Cytoband	p36.11
Chromosome location (bp)	26432282 - 26471294
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000117682 (version 83.38)
Entrez gene	79947
UniProt	Q86SQ9 (UniProt - Evidence at protein level)
neXtProt	NX_Q86SQ9
Antibodypedia	DHDDS antibodies

PROTEIN BROWSER

DHDDS-001	DHDDS-005	DHDDS-006	DHDDS-007	DHDDS-008	DHDDS-009	DHDDS-010	DHDDS-011	DHDDS-012	DHDDS-013	DHDDS-015	DHDDS-018	DHDDS-020	DHDDS-022	DHDDS-023	DHDDS-025

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DHDDS-001 ENSP00000353104 ENST00000360009	Q86SQ9 [Direct mapping] Dehydrodolichyl diphosphate syntase complex subunit DHDDS Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002094 [polyprenyltransferase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006489 [dolichyl diphosphate biosynthetic process] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	334 aa 38.8 kDa	No	0
DHDDS-005 ENSP00000363300 ENST00000374185	Q5T0A1 [Direct mapping] Dehydrodolichyl diphosphate syntase complex subunit DHDDS Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] Show all	209 aa 24.1 kDa	No	0
DHDDS-006 ENSP00000399177 ENST00000427245	E9PI09 [Direct mapping] Dehydrodolichyl diphosphate syntase complex subunit DHDDS Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] Show all	198 aa 22.8 kDa	No	0
DHDDS-007 ENSP00000405604 ENST00000436153	Q5T0A2 [Direct mapping] Dehydrodolichyl diphosphate syntase complex subunit DHDDS Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] Show all	173 aa 20 kDa	No	0
DHDDS-008 ENSP00000397584 ENST00000430232	Q5T0A3 [Direct mapping] Dehydrodolichyl diphosphate syntase complex subunit DHDDS Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] Show all	216 aa 25.2 kDa	No	0
DHDDS-009 ENSP00000434984 ENST00000525682	Q86SQ9 [Direct mapping] Dehydrodolichyl diphosphate syntase complex subunit DHDDS Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002094 [polyprenyltransferase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006489 [dolichyl diphosphate biosynthetic process] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	299 aa 34.8 kDa	No	0
DHDDS-010 ENSP00000393961 ENST00000416052	H0Y4T1 [Direct mapping] Dehydrodolichyl diphosphate syntase complex subunit DHDDS Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] Show all	162 aa 18.5 kDa	No	0
DHDDS-011 ENSP00000236342 ENST00000236342	Q86SQ9 [Direct mapping] Dehydrodolichyl diphosphate syntase complex subunit DHDDS Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002094 [polyprenyltransferase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006489 [dolichyl diphosphate biosynthetic process] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	333 aa 38.7 kDa	No	0
DHDDS-012 ENSP00000399781 ENST00000431933	Q5T0A6 [Direct mapping] Dehydrodolichyl diphosphate syntase complex subunit DHDDS Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] Show all	169 aa 19.6 kDa	No	0
DHDDS-013 ENSP00000434219 ENST00000526219	Q86SQ9 [Direct mapping] Dehydrodolichyl diphosphate syntase complex subunit DHDDS Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002094 [polyprenyltransferase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006489 [dolichyl diphosphate biosynthetic process] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	294 aa 34.3 kDa	No	0
DHDDS-015 ENSP00000436764 ENST00000531312	E9PI64 [Direct mapping] Dehydrodolichyl diphosphate syntase complex subunit DHDDS Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] Show all	131 aa 15.2 kDa	No	0
DHDDS-018 ENSP00000436119 ENST00000533087	E9PR24 [Direct mapping] Dehydrodolichyl diphosphate syntase complex subunit DHDDS Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] Show all	166 aa 19.2 kDa	No	0
DHDDS-020 ENSP00000434185 ENST00000525165	E9PRS7 [Direct mapping] Dehydrodolichyl diphosphate syntase complex subunit DHDDS Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] Show all	122 aa 14.2 kDa	No	0
DHDDS-022 ENSP00000433976 ENST00000525546	E9PSH7 [Direct mapping] Dehydrodolichyl diphosphate syntase complex subunit DHDDS Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] Show all	85 aa 9.9 kDa	No	0
DHDDS-023 ENSP00000431407 ENST00000525326	E9PL99 [Direct mapping] Dehydrodolichyl diphosphate syntase complex subunit DHDDS Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] Show all	71 aa 8.3 kDa	No	0
DHDDS-025 ENSP00000433491 ENST00000530781	E9PKJ5 [Direct mapping] Dehydrodolichyl diphosphate syntase complex subunit DHDDS Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups] Show all	60 aa 7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.