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A majority of adenocarcinomas showed moderate to strong cytoplasmic immunoreactivity. Prostate and renal cancers as well as remaining tumor types e.g. squamous cell carcinomas and melanomas were negative.
Serous ovarian cancers, colorectal, breast, pancreatic, endometrial cancers as well as adenocarcinomas in cervix and lung displayed strong cytoplasmic immunoreactivity. Remaining cancer tissues were in general negative.
This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]